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Highly Accessed Minireview

Obesity genes: so close and yet so far...

Daniel Pomp12* and Karen L Mohlke2

Author Affiliations

1 Departments of Nutrition, Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599-7461, USA

2 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, USA

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Journal of Biology 2008, 7:36  doi:10.1186/jbiol93

Published: 27 November 2008

Abstract

Little is known about genetic variants that predispose individuals toward leanness or fatness. This minireview highlights recent advances in the study of human populations, animal models and synergistic efforts as described by De Luca and colleagues in BMC Genetics, which are beginning to harvest low-hanging fruit in the search for obesity genes.