Figure 1.

The Collaborative Cross for complex trait analysis. Starting with eight inbred mouse strains capturing 90% of all genetic variation in mice, a funnel breeding scheme is used to randomize variation. A single breeding funnel results in one immortal CC recombinant inbred line that is a mosaic combination of the eight founder genomes. The CC will consist of multiple independent lines (the target is 1,000), each of which will represent a different yet fixed capture of genetic variation. Figure courtesy of Fernando Pardo-Manuel de Villena and David Threadgill.

Pomp and Mohlke Journal of Biology 2008 7:36   doi:10.1186/jbiol93
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