The Collaborative Cross for complex trait analysis. Starting with eight inbred mouse strains capturing 90% of all genetic variation in mice, a funnel breeding scheme is used to randomize variation. A single breeding funnel results in one immortal CC recombinant inbred line that is a mosaic combination of the eight founder genomes. The CC will consist of multiple independent lines (the target is 1,000), each of which will represent a different yet fixed capture of genetic variation. Figure courtesy of Fernando Pardo-Manuel de Villena and David Threadgill.
Pomp and Mohlke Journal of Biology 2008 7:36 doi:10.1186/jbiol93