Articles

Volume 7 (2008) - April 2008

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Research article   Open Access Highly Accessed

Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system

Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2008, 7:12 (22 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

The chemotherapy drug, 5-fluorouracil, causes delayed degeneration in the central nervous system of animals, a newly identified type of damage that helps explain the cognitive defects or `chemobrain` symptoms associated with cancer treatment.

Minireview   Free Highly Accessed

How chemotherapy damages the central nervous system

Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

Research article   Open Access Highly Accessed

Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.