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Highly Accessed Review

The ribosome returned

Peter B Moore

Author affiliations

Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA

Citation and License

Journal of Biology 2009, 8:8  doi:10.1186/jbiol103

Published: 26 January 2009

Abstract

Since the mid-1990s, insights obtained from electron microscopy and X-ray crystallography have transformed our understanding of how the most important ribozyme in the cell, the ribosome, catalyzes protein synthesis. This review provides a brief account of how this structural revolution came to pass, and the impact it has had on our understanding of how the ribosome decodes messenger RNAs.