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Highly Accessed Opinion

The nature of cell-cycle checkpoints: facts and fallacies

Alexey Khodjakov and Conly L Rieder

Author Affiliations

Wadsworth Center, PO Box 509, Albany, NY 12201-0509, USA

Journal of Biology 2009, 8:88  doi:10.1186/jbiol195

Published: 16 November 2009

Abstract

The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results. We illustrate, using the mitotic checkpoint, problems that can arise from a failure to respect strict definitions and precise terminology.