Table 1

APC subunits in different organisms

S. cerevisiae

S. pombe

Mammals

D. melanogaster

Comments


Core subunits

Apc1

Cut4

Apc1/Tsg24

Apc2

Apc2

Apc2

Cullin domain

Cdc27

Nuc2

Cdc27

TPRs

Apc4

Lid1

Apc4

Apc5

Apc5

Apc5

Cdc16

Cut9

Apc6

TPRs

-

-

Apc7

TPRs

Cdc23

Cut23

Cdc23

TPRs

Apc9

-

-

Doc1

Apc10

Apc10

Doc domain

Apc11

Apc11

Apc11

RING finger

Cdc26

Hcn1

Cdc26

Swm1

Apc13

-

Mnd2

Apc15

-

-

Apc14

-

Activators

Cdc20

Slp1

Cdc20/p55CDC

Fizzy/FZY

WD40 repeats

Cdh1/Hct1

Srw1/Ste9

Cdh1

Fizzy-related/FZR

WD40 repeats

Ama1

Mfr1

Meiosis-specific


Dashes indicate that no homologous subunit has been identified in that species. Most core subunits are not yet identified in Drosophila melanogaster. Motifs in APC subunits include tetratricopeptide repeats (TPRs) and WD40 repeats, both of which form domains that are typically involved in protein-protein interactions. Modified from [6].

Matyskiela et al. Journal of Biology 2009 8:92   doi:10.1186/jbiol184