Generalized immune activation as a direct result of activated CD4+ T cell killing
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* Corresponding author: George Kassiotis gkassio@nimr.mrc.ac.uk
Journal of Biology 2009, 8:93 doi:10.1186/jbiol194
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BioMed Central: 3 citations
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Review
Savita Nair, Wibke Bayer, Mickaël JY Ploquin, George Kassiotis, Kim J Hasenkrug, Ulf Dittmer Retrovirology 2011, 8:76 (26 September 2011) In this review, we discuss contributions from the major CD4+ T cell subpopulations to retroviral immunity. Fundamental concepts obtained from studies on numerous viral infections are presented along with a more detailed analysis of studies on murine Friend virus. The relevance of these studies to HIV immunology and immunotherapy is reviewed.
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Minireview
Life and death as a T lymphocyte: from immune protection to HIV pathogenesis Nienke Vrisekoop, Judith N Mandl, Ronald N Germain Journal of Biology 2009, 8:91 (27 November 2009) Vrisekekoop, Mandl and Germain discuss the consequences of deleting activated CD4 T cells both in HIV infected humans and in engineered mice described in a paper published in Journal of Biology, and how both the similarities and the differences may be instructive.
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Editorial
What we still don't know about AIDS Miranda Robertson Journal of Biology 2009, 8:87 (27 November 2009) |