Research article
Generalized immune activation as a direct result of activated CD4+ T cell killing
1 Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
2 Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
3 Institute for Genetics, University of Cologne, Zülpicher Strasse 47, 50674 Cologne, Germany
4 Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
5 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Journal of Biology 2009, 8:93 doi:10.1186/jbiol194
Published: 27 November 2009Additional files
Additional file 1:
Strategy for targeting of an activatable DTA-encoding gene into the R26 locus.
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Additional file 2:
DTA-mediated deletion of memory and regulatory CD4+ T cells in mixed bone marrow chimeras.
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Additional file 3:
CD4+ T cell number dependency of influenza A virus (IAV)-neutralizing antibody induction.
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Additional file 4:
CD8+ T cell number and phenotype in MHC II-deficient mice.
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Additional file 5:
Effect of microbial translocation on lymphocyte turnover in Ikbkgfl/Y Vil-Cre mice.
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Additional file 6:
Effect of CD4+ T cell reconstitution on CD8+ T cell activation in Tnfrsf4Cre/+ R26Dta/+ mice.
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Additional file 7:
Effect of CD4+ T cell reconstitution on Treg cell number in Tnfrsf4Cre/+ R26Dta/+ mice.
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