Open Access Highly Accessed Research article

Generalized immune activation as a direct result of activated CD4+ T cell killing

Rute Marques1, Adam Williams25, Urszula Eksmond1, Andy Wullaert3, Nigel Killeen4, Manolis Pasparakis3, Dimitris Kioussis2 and George Kassiotis1*

Author Affiliations

1 Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK

2 Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK

3 Institute for Genetics, University of Cologne, Zülpicher Strasse 47, 50674 Cologne, Germany

4 Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA

5 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA

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Journal of Biology 2009, 8:93  doi:10.1186/jbiol194

Published: 27 November 2009

Additional files

Additional file 1:

Strategy for targeting of an activatable DTA-encoding gene into the R26 locus.

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Additional file 2:

DTA-mediated deletion of memory and regulatory CD4+ T cells in mixed bone marrow chimeras.

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Additional file 3:

CD4+ T cell number dependency of influenza A virus (IAV)-neutralizing antibody induction.

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Additional file 4:

CD8+ T cell number and phenotype in MHC II-deficient mice.

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Additional file 5:

Effect of microbial translocation on lymphocyte turnover in Ikbkgfl/Y Vil-Cre mice.

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Additional file 6:

Effect of CD4+ T cell reconstitution on CD8+ T cell activation in Tnfrsf4Cre/+ R26Dta/+ mice.

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Additional file 7:

Effect of CD4+ T cell reconstitution on Treg cell number in Tnfrsf4Cre/+ R26Dta/+ mice.

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