Promoter architecture and the evolvability of gene expression
1 Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
2 VIB Laboratory for Systems Biology, Gaston Geenslaan 1, B-3001 Leuven, Belgium
3 Centre of Microbial and Plant Genetics, CMPG-G&G, K.U. Leuven, Gaston Geenslaan 1, B-3001 Leuven, Belgium
Journal of Biology 2009, 8:95 doi:10.1186/jbiol204Published: 14 December 2009
Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.