Email updates

Keep up to date with the latest news and content from Journal of Biology and BioMed Central.

Highly Accessed Opinion

Promoter architecture and the evolvability of gene expression

Itay Tirosh1*, Naama Barkai1 and Kevin J Verstrepen23

Author Affiliations

1 Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel

2 VIB Laboratory for Systems Biology, Gaston Geenslaan 1, B-3001 Leuven, Belgium

3 Centre of Microbial and Plant Genetics, CMPG-G&G, K.U. Leuven, Gaston Geenslaan 1, B-3001 Leuven, Belgium

For all author emails, please log on.

Journal of Biology 2009, 8:95  doi:10.1186/jbiol204

Published: 14 December 2009

Abstract

Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.