Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street No. 903, Worcester, MA 01605, USA
Journal of Biology 2009, 8:96 doi:10.1186/jbiol207Published: 23 December 2009
The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed.