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Adaptations of proteins to cellular and subcellular pH

Bertrand Garcia-Moreno

Author affiliations

Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA

Citation and License

Journal of Biology 2009, 8:98  doi:10.1186/jbiol199

Published: 2 December 2009

Abstract

Bioinformatics-based searches for correlations between subcellular localization and pI or charge distribution of proteins have failed to detect meaningful correlations. Recent work published in BMC Biology finds that a physicochemical metric of charge distribution correlates better with subcellular pH than does pI.

See research article http://www.biomedcentral.com/1741-7007/7/69 webcite