Scribble at the crossroads
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris cedex 15, France
Journal of Biology 2009, 8:104 doi:10.1186/jbiol190Published: 29 December 2009
Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.