Scribble at the crossroads
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Journal of Biology 2009, 8:104 doi:10.1186/jbiol190Published: 29 December 2009
Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.