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The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics

Pascale Cossart123* and Cristel Archambaud123

Author Affiliations

1 Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F-75015, France

2 Inserm U604, Paris F-75015, France

3 INRA USC2020, Paris F-75015, France

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Journal of Biology 2009, 8:107  doi:10.1186/jbiol202

Published: 30 December 2009

Abstract

A major challenge in bacterial pathogenesis is understanding the molecular basis of the switch from saprophytism to virulence. Following a recent whole-genome transcriptomic analysis using tiling arrays, an article published in BMC Genomics reports the first use of RNA-seq in Listeria monocytogenes in order to identify genes controlled by sigma B, a transcriptional regulator with a critical role in virulence.

See research article http://biomedcentral.com/1471-2164/10/641 webcite