The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics
1 Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F-75015, France
2 Inserm U604, Paris F-75015, France
3 INRA USC2020, Paris F-75015, France
Journal of Biology 2009, 8:107 doi:10.1186/jbiol202Published: 30 December 2009
A major challenge in bacterial pathogenesis is understanding the molecular basis of the switch from saprophytism to virulence. Following a recent whole-genome transcriptomic analysis using tiling arrays, an article published in BMC Genomics reports the first use of RNA-seq in Listeria monocytogenes in order to identify genes controlled by sigma B, a transcriptional regulator with a critical role in virulence.