Figure 2.

Influence of genomic co-localization on gene coexpression as a function of similarity in transcriptional control. Transcriptional control similarity (TCS) is a measure of the similarity in the suite of transcription factors that regulate a pair of genes. A score of zero means no similarity, a score of one means the very same transcription factors regulate the two genes. Mean levels of coexpression of neighboring genes are shown as black circles and of non-neighbors as white squares; error bars represent standard error of the mean. Note that neighboring genes with no transcription factor control similarity (TCS = 0) have, on average, the same level of coexpression as two unlinked genes with TCS = 1. Adapted from [9].