Email updates

Keep up to date with the latest news and content from Journal of Biology and BioMed Central.

Minireview

Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins

Hue Sun Chan* and Zhuqing Zhang

Author affiliations

Department of Biochemistry, Department of Molecular Genetics, and Department of Physics, University of Toronto, 1 King's College Circle, MSB 5207, Toronto, Ontario, M5S 1A8 Canada

For all author emails, please log on.

Citation and License

Journal of Biology 2009, 8:27  doi:10.1186/jbiol126

Published: 13 March 2009

Abstract

A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior.