Minireview
Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
Author affiliations
Department of Biochemistry, Department of Molecular Genetics, and Department of Physics, University of Toronto, 1 King's College Circle, MSB 5207, Toronto, Ontario, M5S 1A8 Canada
Citation and License
Journal of Biology 2009, 8:27 doi:10.1186/jbiol126
Published: 13 March 2009Abstract
A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior.
