Table 1

The 27 genes included in the two signatures

Gene symbol

Gene name

Hu et al. [3]

Tutt et al. [4]

Basal*

16-kinases

GGI


ADM

Adrenomedullin

Yes

Up

ANGPTL4

Angiopoietin-like 4

Yes

C14orf58

Chromosome 14 open reading frame 58

Yes

Up

DDIT4

DNA-damage-inducible transcript 4

Yes

Up

FABP5

Fatty acid binding protein 5 (psoriasis-associated)

Yes

Up

GAL

Galanin

Yes

Up

NDRG1

N-myc downstream regulated gene 1

Yes

Up

NP

Nucleoside phosphorylase

Yes

Up

PLOD1

Procollagen-lysine 1,2-oxoglutarate 5-dioxygenase 1

Yes

Up

RRAGD

Ras-related GTP binding D

Yes

Up

SLC16A3

Solute carrier family 16 (monocarboxylic acid transporters), member 3

Yes

UCHL1

Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Yes

Up

VEGF

Vascular endothelial growth factor

Yes

Up

BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)

Yes

Up

Yes

Yes

CCNB1

Cyclin B1

Yes

Up

Yes

CENPA

Centromere protein A, 17 kDa

Yes

Up

Yes

DC13

DC13 protein

Yes

Yes

DIAPH3

Diaphanous homolog 3 (Drosophila)

Yes

MELK

Maternal embryonic leucine zipper kinase

Yes

Up

Yes

MYBL2

v-Myb myeloblastosis viral oncogene homolog (avian)-like 2

Yes

Up

Yes

ORC6L

Origin recognition complex, subunit 6 like (yeast)

Yes

Up

PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1

Yes

Up

PRR11

Proline rich 11

Yes

RACGAP1

Rac GTPase activating protein 1

Yes

RFC4

Replication factor C (activator 1) 4, 37 kDa

Yes

Up

TK1

Thymidine kinase 1, soluble

Yes

UBE2S

Ubiquitin-conjugating enzyme E2S

Yes

Up


*Genes upregulated in basal versus luminal A tumors [5]; 16-kinase signature [8]; genomic grade index [7].

Bertucci and Birnbaum Journal of Biology 2009 8:28   doi:10.1186/jbiol128