Reconstructing prokaryotic transcriptional regulatory networks: lessons from actinobacteria
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Journal of Biology 2009, 8:29 doi:10.1186/jbiol132Published: 15 April 2009
Reconstruction of transcriptional regulatory networks of uncharacterized bacteria is a main challenge for the post-genomic era. Recent studies, including one in BMC Systems Biology, address this problem in the relatively underexplored actinobacteria clade, which includes major pathogenic and economically relevant taxa.