Relationship between expression similarity between orthologous genes and amount of conserved nonexonic sequence. Proportion of conserved nonexonic sequence defined as Phastcons elements (a, b) and human bases in non-collinear alignment (c, d) compared against the conservation of gene expression by the binary measure (a, c) and Pearson measure (normalized intensities) versus pufferfish (P) (b, d) (see text and Materials and methods for details). Selected TFs are indicated in (b) (see text). Probable TFs as determined by their Ensembl gene descriptions, but that were not identified by our domain analyses, are indicated by †. Spearman rho refers to the Spearman correlation coefficient.
Chan et al. Journal of Biology 2009 8:33 doi:10.1186/jbiol130