Table 1

Prions of mammals, yeast and the filamentous fungus Podospora anserina

Organism

Prion

Protein

Normal function

Prion manifestation


Mammals

TSEs

PrP

Not known

Transmissible spongiform encephalopathy

Saccharomyces cerevisiae

[URE3]

Ure2

Nitrogen catabolite repression

Derepression of nitrogen catabolism enzymes and transporters

[PSI+]

Sup35

Translation termination

Read-through of stop codons

[PIN+]

Rnq1

Not known

Rare seeding of [PSI+], other prions

[SWI+]

Swi1

Chromatin remodeling

Poor growth on glycerol, raffinose, galactose

[MCA]

Mca1

Metacaspase (suspected function in apoptosis)

Unknown

[OCT+]

Cyc8

Repression of CYC7 and other genes

Derepression of transcription

[MOT3+]

Mot3

Transcription factor

Cell-wall changes

Podospora anserina

[Het-s]

HET-s

Heterokaryon incompatibility; meiotic drive (as a prion)

Heterokaryon incompatibility; meiotic drive (as a prion)


Wickner et al. Journal of Biology 2009 8:47   doi:10.1186/jbiol148