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Prions of mammals, yeast and the filamentous fungus Podospora anserina |
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| Organism |
Prion |
Protein |
Normal function |
Prion manifestation |
|
|
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| Mammals |
TSEs |
PrP |
Not known |
Transmissible spongiform encephalopathy |
| Saccharomyces cerevisiae |
[URE3] |
Ure2 |
Nitrogen catabolite repression |
Derepression of nitrogen catabolism enzymes and transporters |
| [PSI+] |
Sup35 |
Translation termination |
Read-through of stop codons |
|
| [PIN+] |
Rnq1 |
Not known |
Rare seeding of [PSI+], other prions |
|
| [SWI+] |
Swi1 |
Chromatin remodeling |
Poor growth on glycerol, raffinose, galactose |
|
| [MCA] |
Mca1 |
Metacaspase (suspected function in apoptosis) |
Unknown |
|
| [OCT+] |
Cyc8 |
Repression of CYC7 and other genes |
Derepression of transcription |
|
| [MOT3+] |
Mot3 |
Transcription factor |
Cell-wall changes |
|
| Podospora anserina |
[Het-s] |
HET-s |
Heterokaryon incompatibility; meiotic drive (as a prion) |
Heterokaryon incompatibility; meiotic drive (as a prion) |
Wickner et al. Journal of Biology 2009 8:47 doi:10.1186/jbiol148 |
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