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Can modular analysis identify disease-associated candidate genes for therapeutics?

Jesper Tegnér

Author affiliations

Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, 171 76 Solna, Stockholm, Sweden

Citation and License

Journal of Biology 2009, 8:48  doi:10.1186/jbiol149

Published: 28 May 2009

Abstract

Complex diseases such as allergy change gene expression in several cell types and tissues. Benson and colleagues have now shown, in a paper in BMC Systems Biology, that this complexity can be studied effectively using an integrated experimental and computational modular analysis. Their strategy revealed a core of allergy-associated genes of potential therapeutic value.