Letting go: modification of cell adhesion during apoptosis
1 The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
2 Institute of Developmental Biology and Cancer, CNRS UMR6543, UniversitéNice – Sophia Antipolis, Parc Valrose, 06108 Nice cedex 2, France
Journal of Biology 2009, 8:49 doi:10.1186/jbiol152Published: 28 May 2009
Apoptosis appears to be a carefully orchestrated process for the ordered dismantling of cells. A recent paper in BMC Developmental Biology shows that the disassembly of adherens junctions during apoptosis in Drosophila is progressive and requires the amino-terminal cleavage of the β-catenin Armadillo by the apoptotic effector caspase DrICE.