Oxidative stress, thermogenesis and evolution of uncoupling proteins

doi:10.1186/jbiol155

Journal of Biology

Volume 8
Issue 6

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Oxidative stress, thermogenesis and evolution of uncoupling proteins

Eduardo Rial¹ and Rafael Zardoya²

¹Centro de Investigaciones Biológicas, CSIC, Ramiro de Maezu 9, 28040 Madrid, Spain

²Museo Nacional de Ciencias Naturales, CSIC, Gutiérrez Abascal 2, 28006 Madrid, Spain

author email corresponding author email

Journal of Biology 2009, 8:58doi:10.1186/jbiol155


Published:	16 June 2009

Abstract

The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.