Oxidative stress, thermogenesis and evolution of uncoupling proteins
1 Centro de Investigaciones Biológicas, CSIC, Ramiro de Maezu 9, 28040 Madrid, Spain
2 Museo Nacional de Ciencias Naturales, CSIC, Gutiérrez Abascal 2, 28006 Madrid, Spain
Journal of Biology 2009, 8:58 doi:10.1186/jbiol155Published: 16 June 2009
The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.