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From bending DNA to diabetes: the curious case of HMGA1

Robert K Semple

Author affiliations

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QR, UK

Citation and License

Journal of Biology 2009, 8:64  doi:10.1186/jbiol164

Published: 27 July 2009

Abstract

Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.