Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme
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Journal of Biology 2009, 8:73 doi:10.1186/jbiol165Published: 27 August 2009
Insulator elements mediate intra- and inter-chromosomal interactions. The insulator protein CCCTC-binding factor (CTCF) is important for insulator function in several animals but a report in BMC Molecular Biology shows that Caenorhabditis elegans, yeast and plants lack CTCF. Alternative proteins may have a similar function in these organisms.