Targeting TNF-α for cancer therapy
1 Division of Gynecologic Oncology, Montefiore Medical Park, 1695 Eastchester Road, Bronx, NY 10461 USA
2 Montefiore Medical Center, Medical Arts Pavilion, 3400 Bainbridge Avenue, MMC-MAP, Bronx, NY 10467, USA
Journal of Biology 2009, 8:85 doi:10.1186/jbiol189Published: 23 October 2009
As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide previously shown to home in on the gastric cancer vasculature with the anti-tumor cytokine TNF-α, and assesses its potential for gastric cancer therapy.