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Targeting TNF-α for cancer therapy

Elizabeth R Burton1 and Steven K Libutti2*

Author Affiliations

1 Division of Gynecologic Oncology, Montefiore Medical Park, 1695 Eastchester Road, Bronx, NY 10461 USA

2 Montefiore Medical Center, Medical Arts Pavilion, 3400 Bainbridge Avenue, MMC-MAP, Bronx, NY 10467, USA

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Journal of Biology 2009, 8:85  doi:10.1186/jbiol189

Published: 23 October 2009

Abstract

As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide previously shown to home in on the gastric cancer vasculature with the anti-tumor cytokine TNF-α, and assesses its potential for gastric cancer therapy.