Targeting TNF-α for cancer therapy
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Journal of Biology 2009, 8:85 doi:10.1186/jbiol189Published: 23 October 2009
As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide previously shown to home in on the gastric cancer vasculature with the anti-tumor cytokine TNF-α, and assesses its potential for gastric cancer therapy.