Articles
Volume 8 (2009) - December 2009
|
Editorial
Top ten in Miranda Robertson Journal of Biology 2009, 8:102 (31 December 2009) |
|
Minireview
The bacterial pathogen Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009) Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.
|
|
Minireview
Forward genetics in Andrew D Peel Journal of Biology 2009, 8:106 (30 December 2009) Peel discusses the merits of the flour beetle over the fruit fly as a new arthropod model organism and describes how a new mutagenesis screen published in BMC Biology increases the usefulness of this creature.
|
|
Minireview
Mapping the protistan 'rare biosphere' Scott C Dawson, Kari D Hagen Journal of Biology 2009, 8:105 (29 December 2009) Dawson and Hagen discuss our current underestimation of the ecological complexity of protist communities in the light of a recent paper in BMC Biology that reports an expanded map of microbial diversity using high throughput sequencing strategy.
|
|
Minireview
Sandrine Etienne-Manneville Journal of Biology 2009, 8:104 (29 December 2009) Etienne-Manneville reviews the intimate link between cell polarity and cell proliferation in the light of a recent study in BMC Biology clarifying the polarity, proliferation and apoptotic pathways downstream of the tumour suppressor Scribble.
|
|
Question & Answer
Q&A: Quantitative approaches to planar polarity and tissue organization Emily Marcinkevicius, Rodrigo Fernandez-Gonzalez, Jennifer A Zallen Journal of Biology 2009, 8:103 (29 December 2009) Zallen and colleagues explain in Q&A format the complex process by which the cells of a tissue establish planar polarity, in which their spatial properties are coordinated, and how failures may be reflected in human developmental defects.
|
|
Editorial
Gene regulation, evolvability and the limits of genomics Miranda Robertson Journal of Biology 2009, 8:94 (24 December 2009) |
|
Minireview
The transcriptome of human monocyte subsets begins to emerge Fernando O Martinez Journal of Biology 2009, 8:99 (23 December 2009) Monocytes are circulating cells that can differentiate into macrophages with either repair and maintenance or inflammatory properties. Martinez discusses recent papers, including one published in BMC Genomics, that help define these distinct properties and thus identify therapeutic targets.
|
|
Minireview
Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC? Amanda Hughes, Oliver J Rando Journal of Biology 2009, 8:96 (23 December 2009) How far is packaging of DNA by nucleosomes directed by DNA sequence? Hughes and Rando discuss this issue in the light of new research in BMC Bioinformatics indicating that nucleosome occupancy is largely determined by the GC content of DNA.
|
|
Minireview
Fishing for the signals that pattern the face Thomas F Schilling, Pierre Le Pabic Journal of Biology 2009, 8:101 (22 December 2009) Craniofacial defects such as cleft lip or palate are common. Schilling and Le Pabic discuss how research on developmental mutants of zebrafish, including one published recently in BMC Developmental Biology, can shed light on craniofacial development.
|
|
Minireview
Coordinated gene expression by post-transcriptional regulons in African trypanosomes Marc Ouellette, Barbara Papadopoulou Journal of Biology 2009, 8:100 (14 December 2009) |
|
Opinion
Promoter architecture and the evolvability of gene expression Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009) Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.
|
|
Minireview
Adaptations of proteins to cellular and subcellular pH Bertrand Garcia-Moreno Journal of Biology 2009, 8:98 (2 December 2009) Protein function and stability are acutely sensitive to pH, which varies in different subcellular compartments. Garcia-Moreno discusses research recently reported in BMC Biology suggesting that adaptation to different compartments is reflected in charge distribution.
|
