Articles
Volume 8 (2009) - July 2009
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Minireview
From bending DNA to diabetes: the curious case of HMGA1 Robert K Semple Journal of Biology 2009, 8:64 (27 July 2009) Robert Semple reviews new findings published in BMC Biology that help explain how deficiencies in the DNA-bending protein HMGA1 can cause type 2 diabetes and low levels of the insulin receptor but paradoxically increased insulin sensitivity.
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Minireview
The where and wherefore of evolutionary breakpoints David Sankoff Journal of Biology 2009, 8:66 (24 July 2009) David Sankoff discusses the properties of chromatin in breakpoint regions and their relevance to evolutionary change in the light of two recent papers in BMC Genomics.
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Minireview
David A Garfield, Gregory A Wray Journal of Biology 2009, 8:65 (21 July 2009) The early stages of development are generally very highly conserved. Garfield and Wray discuss recent genome-scale studies published in BMC Biology and aimed at testing three theories of how selection acts on early embryos.
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Editorial
Of primordial genomes and cooperative kittens Miranda Robertson Journal of Biology 2009, 8:52 (20 July 2009) |
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Research article
Search for a 'Tree of Life' in the thicket of the phylogenetic forest Pere Puigbò, Yuri I Wolf, Eugene V Koonin Journal of Biology 2009, 8:59 (13 July 2009) Koonin and colleagues, comparing a forest of 7000 phylogenetic trees, discern vertical inheritance even at the earliest stages of prokaryotic evolution, despite horizontal gene transfer, but the branching order of the earliest radiations may never be resolved.
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Minireview
Kristen S Swithers, J Peter Gogarten, Gregory P Fournier Journal of Biology 2009, 8:54 (13 July 2009) Gogarten and colleagues review new research by Koonin and colleagues in Journal of Biology and explain how the obstacle of horizontal gene transfer can be circumvented to reconstruct the prokaryotic Tree of Life.
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