Apical polarity in three-dimensional culture systems: where to now?
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Journal of Biology 2010, 9:2 doi:10.1186/jbiol213Published: 21 January 2010
Delineation of the mechanisms that establish and maintain the polarity of epithelial tissues is essential to understanding morphogenesis, tissue specificity and cancer. Three-dimensional culture assays provide a useful platform for dissecting these processes but, as discussed in a recent study in BMC Biology on the culture of mammary gland epithelial cells, multiple parameters that influence the model must be taken into account.