Bunched and Madm: a novel growth-regulatory complex?
Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia and Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia
Journal of Biology 2010, 9:8 doi:10.1186/jbiol219Published: 11 February 2010
By combining Drosophila genetics and proteomics Gluderer et al. report in this issue of Journal of Biology the isolation of a novel growth-regulatory complex consisting of Bunched and Madm. Future study of this complex will address the precise mechanism of growth control, regulation of complex activity, the interface with other growth pathways and a potential role in human cancer.