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No better time to FRET: shedding light on host pathogen interactions

Richard D Hayward1*, Jon D Goguen2 and John M Leong2

Author Affiliations

1 Institute of Structural and Molecular Biology, University College London and Birkbeck, University of London, Gower Street, London WC1E 6BT, UK

2 Department of Molecular Genetics and Microbiology, UMass Medical School, 55 Lake Ave North, Worcester, MA 01655, USA

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Journal of Biology 2010, 9:12 doi:10.1186/jbiol225

Published: 18 February 2010

Abstract

Understanding the spatio-temporal subversion of host cell signaling by bacterial virulence factors is key to combating infectious diseases. Following a recent study by Buntru and co-workers published in BMC Biology, we review how fluorescence (Forster) resonance energy transfer (FRET) has been applied to studying host-pathogen interactions and consider the prospects for its future application.

See research article http://www.biomedcentral.com/1741-7007/7/81 webcite.