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Robust and specific inhibition of microRNAs in Caenorhabditis elegans
Author affiliations
Department of Molecular, Cellular and Development Biology, Yale University, New Haven, CT 06520, USA
Citation and License
Journal of Biology 2010, 9:20 doi:10.1186/jbiol230
Published: 1 April 2010Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo.
See research article http://www.silencejournal.com/content/1/1/9 webcite
