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		Minireview Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'? Maria Grazia Lampugnani Journal of Biology 2010, 9:16 (8 April 2010) Abstract \| Full text \| PDF \| PubMed
		Minireview Robust and specific inhibition of microRNAs in Caenorhabditis elegans Samrat T Kundu, Frank J Slack Journal of Biology 2010, 9:20 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Slack and Samrat Kundu highlight a refinement of the antisense strategy used to inhibit miRNAs in C.elegans, published in Silence, with an adaptation that supports transmission through the germline, and combinatorial use to target several different miRNAs in developing tissues.
		Minireview Genome of a songbird unveiled Raphael Pinaud Journal of Biology 2010, 9:19 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinaud heralds the publication of the zebra finch genome, reviewing some of the most exciting findings of this pioneering effort and explaining how this songbird model offers unique insights into auditory learning, singing behaviour and other biological phenomena.
		Minireview The mathematics of sexual attraction José A Feijó Journal of Biology 2010, 9:18 (29 March 2010) Abstract \| Full text \| PDF \| PubMed
		Minireview Evolution underground: shedding light on the diversification of subterranean insects Carlos Juan, Brent C Emerson Journal of Biology 2010, 9:17 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Juan and Emerson discuss the reconstruction of the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade recently presented in BMC Evolutionary Biology, and the implications for the evolutionary origin of the beetle ancestor.
		Minireview Scale-eating cichlids: from hand(ed) to mouth A Richard Palmer Journal of Biology 2010, 9:11 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Palmer discusses recent studies, including one in BMC Biology, suggesting that mouth bending in scale-eating cichlids cannot be explained by frequency dependent selection alone, but that the behavior of the fish may amplify mouth asymmetry during growth.
		Opinion Top dogs: wolf domestication and wealth Carlos A Driscoll, David W Macdonald Journal of Biology 2010, 9:10 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on a phylogeographic analysis in BMC Biology that supports a Middle Eastern origin of small dogs, Driscoll and Macdonald speculate on the implications of wolf domestication and size reduction occurring at a time of transition between hunter-gatherer and sedentary societies.
		Minireview No better time to FRET: shedding light on host pathogen interactions Richard D Hayward, Jon D Goguen, John M Leong Journal of Biology 2010, 9:12 (18 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hayward and colleagues discuss the promise of fluorescence resonance energy transfer (FRET)-based techniques to study the spatio-temporal subversion of host cell signaling by pathogens, reviewing the few existing examples of this, which include a recent paper in BMC Biology, to illustrate the power of an approach that has been surprisingly under-exploited to date.
		Minireview Making progress in genetic kin recognition among vertebrates Jane L Hurst, Robert J Beynon Journal of Biology 2010, 9:13 (17 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Highlighting recent research in BMC Evolutionary Biology that analyzes the scent profiles of ring-tailed lemurs in relation to their genetic distance, Hurst and Benyon discuss recent progress and remaining challenges in deciphering how vertebrates recognise kin by their smell.
		Minireview Regeneration review reprise Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.
		Minireview Acoel and platyhelminth models for stem-cell research Alexandra E Bely, James M Sikes Journal of Biology 2010, 9:14 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The bodies of platyhelminth and acoel worms are continually renewed from large pools of somatic stem cells. Bely and Sikes discuss their consequent attractiveness for stem cell research, and how recent studies, including one in BMC Developmental Biology, reveal aspects of the cellular dynamics and molecular basis of stem-cell function in these animals.
		Research article Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila Silvia Gluderer, Erich Brunner, Markus Germann, Virginija Jovaisaite, Changqing Li, Cyrill A Rentsch, Ernst Hafen, Hugo Stocker Journal of Biology 2010, 9:9 (11 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stocker and colleagues identify and analyze a growth-promoting complex in Drosophila, formed between the putative transcription factor BunA, for which human homologs can functionally substitute, and the adaptor protein Madm.
		Minireview Bunched and Madm: a novel growth-regulatory complex? Kieran F Harvey Journal of Biology 2010, 9:8 (11 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reviewing how studies in Drosophila have contributed to understanding signaling pathways involved in cancer, Harvey discusses the implications of a Journal of Biology article reporting a BunA/Madm complex that regulates growth in flies.
		Question & Answer Q&A: What can microfluidics do for stem-cell research? Marie Csete Journal of Biology 2010, 9:1 (11 February 2010) Full text \| PDF \| PubMed
		Minireview Regulation of metabolism in Caenorhabditis elegans longevity Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.
		Minireview Reprogramming of the non-coding transcriptome during brain development Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.
		Minireview The THO complex as a key mRNP biogenesis factor in development and cell differentiation Sonia Jimeno, Andrés Aguilera Journal of Biology 2010, 9:6 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The THO complex is implicated in RNA export from the nucleus, but exactly how is not clear. Jimeno and Aguilera discuss a new report on the THOC5 subunit in BMC Biology that suggests a role in differentiation.
		Minireview SnoPatrol: how many snoRNA genes are there? Paul P Gardner, Alex Bateman, Anthony M Poole Journal of Biology 2010, 9:4 (25 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gardner, Bateman and Poole review the current knowledge of small nucleolar RNAs (snoRNAs) and discuss two BMC Genomic papers reporting the identification of novel snoRNAs and the likelihood that there are many more out there.
		Minireview Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant? Monika Mehta, Hyun-Soo Kim, Michael-Christopher Keogh Journal of Biology 2010, 9:3 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nucleosomes present a variable platform for recruitment of transcriptional and repair machineries because of variant histones and post-translational modifications. Keogh and colleagues discuss reports in BMC Biology and BMC Evolutionary Biology that suggest further complexity, in conserved variants of the variants.
		Minireview Apical polarity in three-dimensional culture systems: where to now? Jamie L Inman, Mina J Bissell Journal of Biology 2010, 9:2 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Minireview The water flea Daphnia - a 'new' model system for ecology and evolution? Angelika Stollewerk Journal of Biology 2010, 9:21 (13 January 2010) Abstract \| Full text \| PDF \| PubMed
		Editorial Top ten in Journal of Biology in 2009: stem cells, influenza, pit bulls, Darwin, and more Miranda Robertson Journal of Biology 2009, 8:102 (31 December 2009) Full text \| PDF \| PubMed
		Minireview The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.
		Minireview Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology Andrew D Peel Journal of Biology 2009, 8:106 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peel discusses the merits of the flour beetle over the fruit fly as a new arthropod model organism and describes how a new mutagenesis screen published in BMC Biology increases the usefulness of this creature.
		Minireview Mapping the protistan 'rare biosphere' Scott C Dawson, Kari D Hagen Journal of Biology 2009, 8:105 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dawson and Hagen discuss our current underestimation of the ecological complexity of protist communities in the light of a recent paper in BMC Biology that reports an expanded map of microbial diversity using high throughput sequencing strategy.
		Minireview Scribble at the crossroads Sandrine Etienne-Manneville Journal of Biology 2009, 8:104 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Etienne-Manneville reviews the intimate link between cell polarity and cell proliferation in the light of a recent study in BMC Biology clarifying the polarity, proliferation and apoptotic pathways downstream of the tumour suppressor Scribble.
		Question & Answer Q&A: Quantitative approaches to planar polarity and tissue organization Emily Marcinkevicius, Rodrigo Fernandez-Gonzalez, Jennifer A Zallen Journal of Biology 2009, 8:103 (29 December 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Zallen and colleagues explain in Q&A format the complex process by which the cells of a tissue establish planar polarity, in which their spatial properties are coordinated, and how failures may be reflected in human developmental defects.
		Editorial Gene regulation, evolvability and the limits of genomics Miranda Robertson Journal of Biology 2009, 8:94 (24 December 2009) Full text \| PDF \| PubMed
		Minireview The transcriptome of human monocyte subsets begins to emerge Fernando O Martinez Journal of Biology 2009, 8:99 (23 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Monocytes are circulating cells that can differentiate into macrophages with either repair and maintenance or inflammatory properties. Martinez discusses recent papers, including one published in BMC Genomics, that help define these distinct properties and thus identify therapeutic targets.
		Minireview Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC? Amanda Hughes, Oliver J Rando Journal of Biology 2009, 8:96 (23 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary How far is packaging of DNA by nucleosomes directed by DNA sequence? Hughes and Rando discuss this issue in the light of new research in BMC Bioinformatics indicating that nucleosome occupancy is largely determined by the GC content of DNA.
		Minireview Fishing for the signals that pattern the face Thomas F Schilling, Pierre Le Pabic Journal of Biology 2009, 8:101 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Craniofacial defects such as cleft lip or palate are common. Schilling and Le Pabic discuss how research on developmental mutants of zebrafish, including one published recently in BMC Developmental Biology, can shed light on craniofacial development.
		Opinion Promoter architecture and the evolvability of gene expression Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.
		Minireview Coordinated gene expression by post-transcriptional regulons in African trypanosomes Marc Ouellette, Barbara Papadopoulou Journal of Biology 2009, 8:100 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Minireview Adaptations of proteins to cellular and subcellular pH Bertrand Garcia-Moreno Journal of Biology 2009, 8:98 (2 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Protein function and stability are acutely sensitive to pH, which varies in different subcellular compartments. Garcia-Moreno discusses research recently reported in BMC Biology suggesting that adaptation to different compartments is reflected in charge distribution.
		Minireview TBP2 is a general transcription factor specialized for female germ cells Ferenc Müller, Làszlò Tora Journal of Biology 2009, 8:97 (30 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mueller and Tora discuss a BMC Biology paper that shows that TBP2 is highly similar to TATA binding proteins but is an oocyte-specific factor and is indispensable for female germ cell development in vertebrates.
		Research article Generalized immune activation as a direct result of activated CD4⁺T cell killing Rute Marques, Adam Williams, Urszula Eksmond, Andy Wullaert, Nigel Killeen, Manolis Pasparakis, Dimitris Kioussis, George Kassiotis Journal of Biology 2009, 8:93 (27 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary HIV causes immunodeficiency by deleting activated CD4 T lymphocytes, but paradoxically also causes general immune activation. Kassiotis and colleagues have mimicked this effect by using genetic engineering to delete activated T cells in mice, and show that in the mice it is due to loss of regulatory T cells.
		Minireview Life and death as a T lymphocyte: from immune protection to HIV pathogenesis Nienke Vrisekoop, Judith N Mandl, Ronald N Germain Journal of Biology 2009, 8:91 (27 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vrisekekoop, Mandl and Germain discuss the consequences of deleting activated CD4 T cells both in HIV infected humans and in engineered mice described in a paper published in Journal of Biology, and how both the similarities and the differences may be instructive.
		Editorial What we still don't know about AIDS Miranda Robertson Journal of Biology 2009, 8:87 (27 November 2009) Full text \| PDF \| PubMed
		Minireview The gene complement of the ancestral bilaterian - was Urbilateria a monster? David J Miller, Eldon E Ball Journal of Biology 2009, 8:89 (19 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bilateral animals have selectively shed genes as they evolved from their hypothetical ancestor, Urbilateria. Miller and Ball review this genomic history and ask if a recent paper in BMC Evolutionary Biology points to an ancestral worm.
		Opinion The nature of cell-cycle checkpoints: facts and fallacies Alexey Khodjakov, Conly L Rieder Journal of Biology 2009, 8:88 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The development of the checkpoint concept was a landmark in the understanding of cell cycle control, but Alexey Khodjakov and Conly Rieder argue that it is widely misunderstood, to the detriment of progress in cell cycle research.
		Minireview An expanded evolutionary role for flower symmetry genes Lena C Hileman, Pilar Cubas Journal of Biology 2009, 8:90 (6 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cubas and Hileman discuss studies, including one in BMC Evolutionary Biology, showing that the CYC-like genes that control floral symmetry have profound effects on other features and have been recruited to diverse roles in floral evolution.
		Review Mechanisms of ubiquitin transfer by the anaphase-promoting complex Mary E Matyskiela, Monica C Rodrigo-Brenni, David O Morgan Journal of Biology 2009, 8:92 (26 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The anaphase-promoting complex (APC) is a giant ubiquitin ligase required for separation of the chromosomes at metaphase and exit from mitosis. David Morgan and colleagues explain how this complex combines specificity with flexibility, with implications for regulation by ubiquitination in general.
		Minireview Targeting TNF-α for cancer therapy Elizabeth R Burton, Steven K Libutti Journal of Biology 2009, 8:85 (23 October 2009) Abstract \| Full text \| PDF \| PubMed
		Minireview TEs or not TEs? That is the evolutionary question Keren Vaknin, Amir Goren, Gil Ast Journal of Biology 2009, 8:83 (23 October 2009) Abstract \| Full text \| PDF \| PubMed
		Opinion Molecular machines or pleiomorphic ensembles: signaling complexes revisited Bruce J Mayer, Michael L Blinov, Leslie M Loew Journal of Biology 2009, 8:81 (16 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intracellular signaling complexes are not machines but form and dissolve in myriad combinations. Bruce Mayer argues in a new series called Ockham's broom that it is time to confront this reality with modern imaging and mathematical tools.
		Editorial Ockham's broom: A new series Miranda Robertson Journal of Biology 2009, 8:79 (16 October 2009) Full text \| PDF \| PubMed
		Minireview Decoding the multifaceted HIV-1 virus-host interactome Eric Y Chan, Marcus J Korth, Michael G Katze Journal of Biology 2009, 8:84 (13 October 2009) Abstract \| Full text \| PDF \| PubMed
		Minireview Adaptation by introgression Michael L Arnold, Noland H Martin Journal of Biology 2009, 8:82 (13 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Question & Answer Q&A: What are pharmacological chaperones and why are they interesting? Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009) Full text \| PDF \| PubMed \| Editor’s summary Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
		Minireview The effects of lipids on channel function Anthony G Lee Journal of Biology 2009, 8:86 (6 October 2009) Abstract \| Full text \| PDF \| PubMed

	All
		Minireview Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'? Maria Grazia Lampugnani Journal of Biology 2010, 9:16 (8 April 2010) Abstract \| Full text \| PDF \| PubMed
		Minireview Robust and specific inhibition of microRNAs in Caenorhabditis elegans Samrat T Kundu, Frank J Slack Journal of Biology 2010, 9:20 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Slack and Samrat Kundu highlight a refinement of the antisense strategy used to inhibit miRNAs in C.elegans, published in Silence, with an adaptation that supports transmission through the germline, and combinatorial use to target several different miRNAs in developing tissues.
		Minireview Genome of a songbird unveiled Raphael Pinaud Journal of Biology 2010, 9:19 (1 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pinaud heralds the publication of the zebra finch genome, reviewing some of the most exciting findings of this pioneering effort and explaining how this songbird model offers unique insights into auditory learning, singing behaviour and other biological phenomena.
		Minireview The mathematics of sexual attraction José A Feijó Journal of Biology 2010, 9:18 (29 March 2010) Abstract \| Full text \| PDF \| PubMed
		Minireview Evolution underground: shedding light on the diversification of subterranean insects Carlos Juan, Brent C Emerson Journal of Biology 2010, 9:17 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Juan and Emerson discuss the reconstruction of the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade recently presented in BMC Evolutionary Biology, and the implications for the evolutionary origin of the beetle ancestor.
		Minireview Scale-eating cichlids: from hand(ed) to mouth A Richard Palmer Journal of Biology 2010, 9:11 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Palmer discusses recent studies, including one in BMC Biology, suggesting that mouth bending in scale-eating cichlids cannot be explained by frequency dependent selection alone, but that the behavior of the fish may amplify mouth asymmetry during growth.
		Opinion Top dogs: wolf domestication and wealth Carlos A Driscoll, David W Macdonald Journal of Biology 2010, 9:10 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on a phylogeographic analysis in BMC Biology that supports a Middle Eastern origin of small dogs, Driscoll and Macdonald speculate on the implications of wolf domestication and size reduction occurring at a time of transition between hunter-gatherer and sedentary societies.
		Minireview No better time to FRET: shedding light on host pathogen interactions Richard D Hayward, Jon D Goguen, John M Leong Journal of Biology 2010, 9:12 (18 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hayward and colleagues discuss the promise of fluorescence resonance energy transfer (FRET)-based techniques to study the spatio-temporal subversion of host cell signaling by pathogens, reviewing the few existing examples of this, which include a recent paper in BMC Biology, to illustrate the power of an approach that has been surprisingly under-exploited to date.
		Minireview Making progress in genetic kin recognition among vertebrates Jane L Hurst, Robert J Beynon Journal of Biology 2010, 9:13 (17 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Highlighting recent research in BMC Evolutionary Biology that analyzes the scent profiles of ring-tailed lemurs in relation to their genetic distance, Hurst and Benyon discuss recent progress and remaining challenges in deciphering how vertebrates recognise kin by their smell.
		Minireview Regeneration review reprise Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.
		Minireview Acoel and platyhelminth models for stem-cell research Alexandra E Bely, James M Sikes Journal of Biology 2010, 9:14 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The bodies of platyhelminth and acoel worms are continually renewed from large pools of somatic stem cells. Bely and Sikes discuss their consequent attractiveness for stem cell research, and how recent studies, including one in BMC Developmental Biology, reveal aspects of the cellular dynamics and molecular basis of stem-cell function in these animals.
		Research article Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila Silvia Gluderer, Erich Brunner, Markus Germann, Virginija Jovaisaite, Changqing Li, Cyrill A Rentsch, Ernst Hafen, Hugo Stocker Journal of Biology 2010, 9:9 (11 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stocker and colleagues identify and analyze a growth-promoting complex in Drosophila, formed between the putative transcription factor BunA, for which human homologs can functionally substitute, and the adaptor protein Madm.
		Minireview Bunched and Madm: a novel growth-regulatory complex? Kieran F Harvey Journal of Biology 2010, 9:8 (11 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Reviewing how studies in Drosophila have contributed to understanding signaling pathways involved in cancer, Harvey discusses the implications of a Journal of Biology article reporting a BunA/Madm complex that regulates growth in flies.
		Question & Answer Q&A: What can microfluidics do for stem-cell research? Marie Csete Journal of Biology 2010, 9:1 (11 February 2010) Full text \| PDF \| PubMed
		Minireview Regulation of metabolism in Caenorhabditis elegans longevity Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.
		Minireview Reprogramming of the non-coding transcriptome during brain development Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.
		Minireview The THO complex as a key mRNP biogenesis factor in development and cell differentiation Sonia Jimeno, Andrés Aguilera Journal of Biology 2010, 9:6 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The THO complex is implicated in RNA export from the nucleus, but exactly how is not clear. Jimeno and Aguilera discuss a new report on the THOC5 subunit in BMC Biology that suggests a role in differentiation.
		Minireview SnoPatrol: how many snoRNA genes are there? Paul P Gardner, Alex Bateman, Anthony M Poole Journal of Biology 2010, 9:4 (25 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gardner, Bateman and Poole review the current knowledge of small nucleolar RNAs (snoRNAs) and discuss two BMC Genomic papers reporting the identification of novel snoRNAs and the likelihood that there are many more out there.
		Minireview Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant? Monika Mehta, Hyun-Soo Kim, Michael-Christopher Keogh Journal of Biology 2010, 9:3 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nucleosomes present a variable platform for recruitment of transcriptional and repair machineries because of variant histones and post-translational modifications. Keogh and colleagues discuss reports in BMC Biology and BMC Evolutionary Biology that suggest further complexity, in conserved variants of the variants.
		Minireview Apical polarity in three-dimensional culture systems: where to now? Jamie L Inman, Mina J Bissell Journal of Biology 2010, 9:2 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Minireview The water flea Daphnia - a 'new' model system for ecology and evolution? Angelika Stollewerk Journal of Biology 2010, 9:21 (13 January 2010) Abstract \| Full text \| PDF \| PubMed
		Editorial Top ten in Journal of Biology in 2009: stem cells, influenza, pit bulls, Darwin, and more Miranda Robertson Journal of Biology 2009, 8:102 (31 December 2009) Full text \| PDF \| PubMed
		Minireview The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.
		Minireview Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology Andrew D Peel Journal of Biology 2009, 8:106 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peel discusses the merits of the flour beetle over the fruit fly as a new arthropod model organism and describes how a new mutagenesis screen published in BMC Biology increases the usefulness of this creature.
		Minireview Mapping the protistan 'rare biosphere' Scott C Dawson, Kari D Hagen Journal of Biology 2009, 8:105 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dawson and Hagen discuss our current underestimation of the ecological complexity of protist communities in the light of a recent paper in BMC Biology that reports an expanded map of microbial diversity using high throughput sequencing strategy.
		Minireview Scribble at the crossroads Sandrine Etienne-Manneville Journal of Biology 2009, 8:104 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Etienne-Manneville reviews the intimate link between cell polarity and cell proliferation in the light of a recent study in BMC Biology clarifying the polarity, proliferation and apoptotic pathways downstream of the tumour suppressor Scribble.
		Question & Answer Q&A: Quantitative approaches to planar polarity and tissue organization Emily Marcinkevicius, Rodrigo Fernandez-Gonzalez, Jennifer A Zallen Journal of Biology 2009, 8:103 (29 December 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Zallen and colleagues explain in Q&A format the complex process by which the cells of a tissue establish planar polarity, in which their spatial properties are coordinated, and how failures may be reflected in human developmental defects.
		Editorial Gene regulation, evolvability and the limits of genomics Miranda Robertson Journal of Biology 2009, 8:94 (24 December 2009) Full text \| PDF \| PubMed
		Minireview The transcriptome of human monocyte subsets begins to emerge Fernando O Martinez Journal of Biology 2009, 8:99 (23 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Monocytes are circulating cells that can differentiate into macrophages with either repair and maintenance or inflammatory properties. Martinez discusses recent papers, including one published in BMC Genomics, that help define these distinct properties and thus identify therapeutic targets.
		Minireview Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC? Amanda Hughes, Oliver J Rando Journal of Biology 2009, 8:96 (23 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary How far is packaging of DNA by nucleosomes directed by DNA sequence? Hughes and Rando discuss this issue in the light of new research in BMC Bioinformatics indicating that nucleosome occupancy is largely determined by the GC content of DNA.
		Minireview Fishing for the signals that pattern the face Thomas F Schilling, Pierre Le Pabic Journal of Biology 2009, 8:101 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Craniofacial defects such as cleft lip or palate are common. Schilling and Le Pabic discuss how research on developmental mutants of zebrafish, including one published recently in BMC Developmental Biology, can shed light on craniofacial development.
		Opinion Promoter architecture and the evolvability of gene expression Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.
		Minireview Coordinated gene expression by post-transcriptional regulons in African trypanosomes Marc Ouellette, Barbara Papadopoulou Journal of Biology 2009, 8:100 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Minireview Adaptations of proteins to cellular and subcellular pH Bertrand Garcia-Moreno Journal of Biology 2009, 8:98 (2 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Protein function and stability are acutely sensitive to pH, which varies in different subcellular compartments. Garcia-Moreno discusses research recently reported in BMC Biology suggesting that adaptation to different compartments is reflected in charge distribution.
		Minireview TBP2 is a general transcription factor specialized for female germ cells Ferenc Müller, Làszlò Tora Journal of Biology 2009, 8:97 (30 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mueller and Tora discuss a BMC Biology paper that shows that TBP2 is highly similar to TATA binding proteins but is an oocyte-specific factor and is indispensable for female germ cell development in vertebrates.
		Research article Generalized immune activation as a direct result of activated CD4⁺T cell killing Rute Marques, Adam Williams, Urszula Eksmond, Andy Wullaert, Nigel Killeen, Manolis Pasparakis, Dimitris Kioussis, George Kassiotis Journal of Biology 2009, 8:93 (27 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary HIV causes immunodeficiency by deleting activated CD4 T lymphocytes, but paradoxically also causes general immune activation. Kassiotis and colleagues have mimicked this effect by using genetic engineering to delete activated T cells in mice, and show that in the mice it is due to loss of regulatory T cells.
		Minireview Life and death as a T lymphocyte: from immune protection to HIV pathogenesis Nienke Vrisekoop, Judith N Mandl, Ronald N Germain Journal of Biology 2009, 8:91 (27 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vrisekekoop, Mandl and Germain discuss the consequences of deleting activated CD4 T cells both in HIV infected humans and in engineered mice described in a paper published in Journal of Biology, and how both the similarities and the differences may be instructive.
		Editorial What we still don't know about AIDS Miranda Robertson Journal of Biology 2009, 8:87 (27 November 2009) Full text \| PDF \| PubMed
		Minireview The gene complement of the ancestral bilaterian - was Urbilateria a monster? David J Miller, Eldon E Ball Journal of Biology 2009, 8:89 (19 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bilateral animals have selectively shed genes as they evolved from their hypothetical ancestor, Urbilateria. Miller and Ball review this genomic history and ask if a recent paper in BMC Evolutionary Biology points to an ancestral worm.
		Opinion The nature of cell-cycle checkpoints: facts and fallacies Alexey Khodjakov, Conly L Rieder Journal of Biology 2009, 8:88 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The development of the checkpoint concept was a landmark in the understanding of cell cycle control, but Alexey Khodjakov and Conly Rieder argue that it is widely misunderstood, to the detriment of progress in cell cycle research.
		Minireview An expanded evolutionary role for flower symmetry genes Lena C Hileman, Pilar Cubas Journal of Biology 2009, 8:90 (6 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cubas and Hileman discuss studies, including one in BMC Evolutionary Biology, showing that the CYC-like genes that control floral symmetry have profound effects on other features and have been recruited to diverse roles in floral evolution.
		Review Mechanisms of ubiquitin transfer by the anaphase-promoting complex Mary E Matyskiela, Monica C Rodrigo-Brenni, David O Morgan Journal of Biology 2009, 8:92 (26 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The anaphase-promoting complex (APC) is a giant ubiquitin ligase required for separation of the chromosomes at metaphase and exit from mitosis. David Morgan and colleagues explain how this complex combines specificity with flexibility, with implications for regulation by ubiquitination in general.
		Minireview Targeting TNF-α for cancer therapy Elizabeth R Burton, Steven K Libutti Journal of Biology 2009, 8:85 (23 October 2009) Abstract \| Full text \| PDF \| PubMed
		Minireview TEs or not TEs? That is the evolutionary question Keren Vaknin, Amir Goren, Gil Ast Journal of Biology 2009, 8:83 (23 October 2009) Abstract \| Full text \| PDF \| PubMed
		Opinion Molecular machines or pleiomorphic ensembles: signaling complexes revisited Bruce J Mayer, Michael L Blinov, Leslie M Loew Journal of Biology 2009, 8:81 (16 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intracellular signaling complexes are not machines but form and dissolve in myriad combinations. Bruce Mayer argues in a new series called Ockham's broom that it is time to confront this reality with modern imaging and mathematical tools.
		Editorial Ockham's broom: A new series Miranda Robertson Journal of Biology 2009, 8:79 (16 October 2009) Full text \| PDF \| PubMed
		Minireview Decoding the multifaceted HIV-1 virus-host interactome Eric Y Chan, Marcus J Korth, Michael G Katze Journal of Biology 2009, 8:84 (13 October 2009) Abstract \| Full text \| PDF \| PubMed
		Minireview Adaptation by introgression Michael L Arnold, Noland H Martin Journal of Biology 2009, 8:82 (13 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Question & Answer Q&A: What are pharmacological chaperones and why are they interesting? Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009) Full text \| PDF \| PubMed \| Editor’s summary Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
		Minireview The effects of lipids on channel function Anthony G Lee Journal of Biology 2009, 8:86 (6 October 2009) Abstract \| Full text \| PDF \| PubMed