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Oxidative stress, thermogenesis and evolution of uncoupling proteins

Eduardo Rial, Rafael Zardoya Journal of Biology 2009, 8:58 (16 June 2009)

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Q&A: Cooperativity

James E Ferrell Journal of Biology 2009, 8:53 (16 June 2009)

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James Ferrell explains in Q&A format how cooperativity can tune the behaviour of biological macromolecules to their physiological functions, and can be achieved in many different ways.

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Influenza: one or two more questions

Miranda Robertson Journal of Biology 2009, 8:45 (12 June 2009)

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Transcription in mosquito hemocytes in response to pathogen exposure

Julián F Hillyer Journal of Biology 2009, 8:51 (5 June 2009)

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Identification of infection-fighting genes in mosquitoes could be used to genetically modify insects that are unable to transmit disease-causing pathogens such as the malarial Plasmodium parasite: Hillyer discusses recent work published in BMC Genomics.

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Fish 'n' TRIMs

Louis Du Pasquier Journal of Biology 2009, 8:50 (29 May 2009)

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Letting go: modification of cell adhesion during apoptosis

Magali Suzanne, Hermann Steller Journal of Biology 2009, 8:49 (28 May 2009)

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Can modular analysis identify disease-associated candidate genes for therapeutics?

Jesper Tegnér Journal of Biology 2009, 8:48 (28 May 2009)

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Biologists who count*

Miranda Robertson Journal of Biology 2009, 8:34 (27 May 2009)

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Prion variants, species barriers, generation and propagation

Reed B Wickner, Herman K Edskes, Frank Shewmaker, Dmitry Kryndushkin, Julie Nemecek Journal of Biology 2009, 8:47 (26 May 2009)

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Reed Wickner and colleagues discuss a recent paper in BMC Biology on yeast prions that helps shed light on how new variants can overcome species barriers.

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Q&A: What do we know about influenza and what can we do about it?

Peter C Doherty, Stephen J Turner Journal of Biology 2009, 8:46 (26 May 2009)

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Peter Doherty and Stephen Turner explain in Q&A format what we know of what determines the pathogenicity and transmissibility of influenza viruses, and the prospects for effective protection.

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Notch signaling, the segmentation clock, and the patterning of vertebrate somites

Julian Lewis, Anja Hanisch, Maxine Holder Journal of Biology 2009, 8:44 (22 May 2009)

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Julian Lewis and colleagues review the part played by the Notch signaling pathway in the emergence of somites from the embryonic mesoderm and their later differentiation.

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Q&A: Epistasis

Frederick P Roth, Howard D Lipshitz, Brenda J Andrews Journal of Biology 2009, 8:35 (22 May 2009)

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The term epistasis has at least three meanings in biology. Brenda Andrews and colleagues explain in Q&A format how in its classical sense, epistasis allows biological pathways to be defined.

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Parental squabbles and genome expression: lessons from the polyploids

Daniela Pignatta, Luca Comai Journal of Biology 2009, 8:43 (1 May 2009)

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Many plant species have evolved from hybrids that have retained the diploid genomes of both parents; Pignatta and Comai discuss a study in BMC Biology on cotton allopolyploids illustrating the novel patterns of expression that can result.

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Natural and engineered mosquito immunity

Luke Alphey Journal of Biology 2009, 8:40 (1 May 2009)

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Alphey reviews recent genetic approaches to mosquito control including one published in BMC Microbiology based on depression of mosquito populations through suppression of the insect's innate immunity to virus infections.

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How do terrestrial Antarctic organisms survive in their harsh environment?

David A Wharton, Craig J Marshall Journal of Biology 2009, 8:39 (29 April 2009)

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Wharton and Marshall discuss studies in BMC Genomics that identify genes and proteins involved in protecting Antarctic nematodes during desiccation, a strategy they developed to survive in a harsh environment.

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The genetics of gender and life span

John Tower, Michelle Arbeitman Journal of Biology 2009, 8:38 (29 April 2009)

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Tower and Arbeitman discuss two studies in BMC Evolutionary Biology showing that the genetic differences between male and female seed beetles and in fruit flies have a significant effect upon aging and life span.

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Why do taste cells generate action potentials?

Aurelie Vandenbeuch, Sue C Kinnamon Journal of Biology 2009, 8:42 (28 April 2009)

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Vandenbeuch and Kinnamon discuss a study in BMC Neuroscience that identifies three genes encoding the tetrodotoxin-sensitive Na+ currents that underlie action potentials in taste cells, providing insights into their physiological significance in taste transduction.

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The origin and evolution of lactation

Anthony V Capuco, R Michael Akers Journal of Biology 2009, 8:37 (24 April 2009)

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Capuco and Akers review the biology of lactation and discuss a new report in Genome Biology that compares the bovine genome with six other mammalian genomes to study how lactation and its regulation evolved.

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The cattle genome reveals its secrets

David W Burt Journal of Biology 2009, 8:36 (24 April 2009)

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Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.

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Is genetic diversity really higher in large populations?

Hans Ellegren Journal of Biology 2009, 8:41 (21 April 2009)

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Hans Ellegren discusses a study in BMC Evolutionary Biology that shows that avian mtDNA diversity patterns are influenced by variations of mutation rate rather than population size.

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Q&A: Genetic analysis of quantitative traits

Trudy FC Mackay Journal of Biology 2009, 8:23 (17 April 2009)

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Quantitative traits, such as human height and cholesterol levels, are controlled by large numbers of genes with small effects, and cannot be analyzed by Mendelian genetics. Trudy MacKay explains in Q&A format what is required to identify the many contributing genes for these traits.

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Teaching new dogs old tricks

Miranda Robertson Journal of Biology 2009, 8:22 (17 April 2009)

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Conservation of core gene expression in vertebrate tissues

Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009)

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High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.

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The genomic 'inner fish' and a regulatory enigma in the vertebrates

John Malone, Brian Oliver Journal of Biology 2009, 8:32 (16 April 2009)

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Brian Oliver and John Malone invoke our 'inner fish' in their commentary on new research in Journal of Biology which shows high conservation of tissue-specific gene expression from fish to human but without corresponding conservation in the gene regulatory sequences.

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Exploiting the promiscuity of imatinib

Shun J Lee, Jean YJ Wang Journal of Biology 2009, 8:30 (15 April 2009)

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Lee and Wang discuss how the structural flexibility of the cancer drug imatinib (Gleevec) accounts for the drug's off-target promiscuity, illustrated by a structural study published in BMC Structural Biology.

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