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Oxidative stress, thermogenesis and evolution of uncoupling proteins
Eduardo Rial, Rafael Zardoya Journal of Biology 2009, 8:58 (16 June 2009)
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Q&A: Cooperativity
James E Ferrell Journal of Biology 2009, 8:53 (16 June 2009)
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Editor’s summary
James Ferrell explains in Q&A format how cooperativity can tune the behaviour of biological macromolecules to their physiological functions, and can be achieved in many different ways.
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Influenza: one or two more questions
Miranda Robertson Journal of Biology 2009, 8:45 (12 June 2009)
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Transcription in mosquito hemocytes in response to pathogen exposure
Julián F Hillyer Journal of Biology 2009, 8:51 (5 June 2009)
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Identification of infection-fighting genes in mosquitoes could be used to genetically modify insects that are unable to transmit disease-causing pathogens such as the malarial Plasmodium parasite: Hillyer discusses recent work published in BMC Genomics.
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Fish 'n' TRIMs
Louis Du Pasquier Journal of Biology 2009, 8:50 (29 May 2009)
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Letting go: modification of cell adhesion during apoptosis
Magali Suzanne, Hermann Steller Journal of Biology 2009, 8:49 (28 May 2009)
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Can modular analysis identify disease-associated candidate genes for therapeutics?
Jesper Tegnér Journal of Biology 2009, 8:48 (28 May 2009)
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Biologists who count*
Miranda Robertson Journal of Biology 2009, 8:34 (27 May 2009)
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Prion variants, species barriers, generation and propagation
Reed B Wickner, Herman K Edskes, Frank Shewmaker, Dmitry Kryndushkin, Julie Nemecek Journal of Biology 2009, 8:47 (26 May 2009)
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Reed Wickner and colleagues discuss a recent paper in BMC Biology on yeast prions that helps shed light on how new variants can overcome species barriers.
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Q&A: What do we know about influenza and what can we do about it?
Peter C Doherty, Stephen J Turner Journal of Biology 2009, 8:46 (26 May 2009)
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Peter Doherty and Stephen Turner explain in Q&A format what we know of what determines the pathogenicity and transmissibility of influenza viruses, and the prospects for effective protection.
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Notch signaling, the segmentation clock, and the patterning of vertebrate somites
Julian Lewis, Anja Hanisch, Maxine Holder Journal of Biology 2009, 8:44 (22 May 2009)
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Julian Lewis and colleagues review the part played by the Notch signaling pathway in the emergence of somites from the embryonic mesoderm and their later differentiation.
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Q&A: Epistasis
Frederick P Roth, Howard D Lipshitz, Brenda J Andrews Journal of Biology 2009, 8:35 (22 May 2009)
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The term epistasis has at least three meanings in biology. Brenda Andrews and colleagues explain in Q&A format how in its classical sense, epistasis allows biological pathways to be defined.
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Parental squabbles and genome expression: lessons from the polyploids
Daniela Pignatta, Luca Comai Journal of Biology 2009, 8:43 (1 May 2009)
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Many plant species have evolved from hybrids that have retained the diploid genomes of both parents; Pignatta and Comai discuss a study in BMC Biology on cotton allopolyploids illustrating the novel patterns of expression that can result.
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Natural and engineered mosquito immunity
Luke Alphey Journal of Biology 2009, 8:40 (1 May 2009)
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Alphey reviews recent genetic approaches to mosquito control including one published in BMC Microbiology based on depression of mosquito populations through suppression of the insect's innate immunity to virus infections.
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How do terrestrial Antarctic organisms survive in their harsh environment?
David A Wharton, Craig J Marshall Journal of Biology 2009, 8:39 (29 April 2009)
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Wharton and Marshall discuss studies in BMC Genomics that identify genes and proteins involved in protecting Antarctic nematodes during desiccation, a strategy they developed to survive in a harsh environment.
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The genetics of gender and life span
John Tower, Michelle Arbeitman Journal of Biology 2009, 8:38 (29 April 2009)
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Tower and Arbeitman discuss two studies in BMC Evolutionary Biology showing that the genetic differences between male and female seed beetles and in fruit flies have a significant effect upon aging and life span.
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Why do taste cells generate action potentials?
Aurelie Vandenbeuch, Sue C Kinnamon Journal of Biology 2009, 8:42 (28 April 2009)
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Vandenbeuch and Kinnamon discuss a study in BMC Neuroscience that identifies three genes encoding the tetrodotoxin-sensitive Na+ currents that underlie action potentials in taste cells, providing insights into their physiological significance in taste transduction.
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The origin and evolution of lactation
Anthony V Capuco, R Michael Akers Journal of Biology 2009, 8:37 (24 April 2009)
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Capuco and Akers review the biology of lactation and discuss a new report in Genome Biology that compares the bovine genome with six other mammalian genomes to study how lactation and its regulation evolved.
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The cattle genome reveals its secrets
David W Burt Journal of Biology 2009, 8:36 (24 April 2009)
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Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.
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Is genetic diversity really higher in large populations?
Hans Ellegren Journal of Biology 2009, 8:41 (21 April 2009)
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Hans Ellegren discusses a study in BMC Evolutionary Biology that shows that avian mtDNA diversity patterns are influenced by variations of mutation rate rather than population size.
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Q&A: Genetic analysis of quantitative traits
Trudy FC Mackay Journal of Biology 2009, 8:23 (17 April 2009)
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Editor’s summary
Quantitative traits, such as human height and cholesterol levels, are controlled by large numbers of genes with small effects, and cannot be analyzed by Mendelian genetics. Trudy MacKay explains in Q&A format what is required to identify the many contributing genes for these traits.
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Teaching new dogs old tricks
Miranda Robertson Journal of Biology 2009, 8:22 (17 April 2009)
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Conservation of core gene expression in vertebrate tissues
Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009)
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High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.
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The genomic 'inner fish' and a regulatory enigma in the vertebrates
John Malone, Brian Oliver Journal of Biology 2009, 8:32 (16 April 2009)
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Editor’s summary
Brian Oliver and John Malone invoke our 'inner fish' in their commentary on new research in Journal of Biology which shows high conservation of tissue-specific gene expression from fish to human but without corresponding conservation in the gene regulatory sequences.
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Exploiting the promiscuity of imatinib
Shun J Lee, Jean YJ Wang Journal of Biology 2009, 8:30 (15 April 2009)
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Editor’s summary
Lee and Wang discuss how the structural flexibility of the cancer drug imatinib (Gleevec) accounts for the drug's off-target promiscuity, illustrated by a structural study published in BMC Structural Biology.
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