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Stage debut for the elusive Drosophila insulin-like growth factor binding protein

Nazif Alic, Linda Partridge Journal of Biology 2008, 7:18 (7 July 2008)

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Making the jump: new insights into the mechanism of trans-translation

Jacek Wower, Iwona K Wower, Christian Zwieb Journal of Biology 2008, 7:17 (30 June 2008)

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Zoological detective stories: the case of the facetotectan crustacean life cycle

Gerhard Scholtz Journal of Biology 2008, 7:16 (26 June 2008)

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Spatially patterned gradients of synaptic connectivity are established early in the developing retina

Susana Cohen-Cory Journal of Biology 2008, 7:15 (9 June 2008)

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Process rather than pattern: finding pine needles in the coevolutionary haystack

David R Nash Journal of Biology 2008, 7:14 (28 May 2008)

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Colugos: obscure mammals glide into the evolutionary limelight

Robert D Martin Journal of Biology 2008, 7:13 (1 May 2008)

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Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system

Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2008, 7:12 (22 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

The chemotherapy drug, 5-fluorouracil, causes delayed degeneration in the central nervous system of animals, a newly identified type of damage that helps explain the cognitive defects or `chemobrain` symptoms associated with cancer treatment.

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How chemotherapy damages the central nervous system

Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008)

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Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.

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Small changes, big results: evolution of morphological discontinuity in mammals

Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008)

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A Caenorhabditis elegans genetic-interaction map wiggles into view

Kristin C Gunsalus Journal of Biology 2008, 7:8 (7 March 2008)

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Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?

Nicolas Vodovar, François Schweisguth Journal of Biology 2008, 7:7 (28 February 2008)

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Reasons for breast cancer heterogeneity

François Bertucci, Daniel Birnbaum Journal of Biology 2008, 7:6 (22 February 2008)

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Great exaptations

Kathleen H Burns, Jef D Boeke Journal of Biology 2008, 7:5 (15 February 2008)

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Semaphorins deployed to repel cell migrants at spinal cord borders

Sophie Chauvet, Geneviève Rougon Journal of Biology 2008, 7:4 (7 February 2008)

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Electrical protein detection in cell lysates using high-density peptide-aptamer microarrays

David Evans, Steven Johnson, Sophie Laurenson, A Giles Davies, Paul Ko Ferrigno, Christoph Wälti Journal of Biology 2008, 7:3 (31 January 2008)

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Specific detection of protein isoforms in whole cell lysates is now more efficient with the arrival of a label-free electronic sensing system consisting of immobilized peptide aptamers on individual gold electrodes at the micron scale.

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The eleven-year switch of peptide aptamers

Pierre Colas Journal of Biology 2008, 7:2 (31 January 2008)

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Metabolic reconfiguration is a regulated response to oxidative stress

Chris M Grant Journal of Biology 2008, 7:1 (25 January 2008)

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Cryptic biodiversity in a changing world

Luciano B Beheregaray, Adalgisa Caccone Journal of Biology 2007, 6:9 (21 December 2007)

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Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach, Sylvia Krobitsch Journal of Biology 2007, 6:10 (21 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Yeast and C. elegans share a conserved cellular mechanism that counteracts the fatal consequences of oxidative stress by enabling the redirection of metabolic flux from glycolysis to the pentose phosphate pathway.

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Landscape genetics goes to sea

Michael Hansen, Jakob Hemmer-Hansen Journal of Biology 2007, 6:6 (16 November 2007)

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A global analysis of genetic interactions in Caenorhabditis elegans

Alexandra B Byrne, Matthew T Weirauch, Victoria Wong, Martina Koeva, Scott J Dixon, Joshua M Stuart, Peter J Roy Journal of Biology 2007, 6:8 (26 September 2007)

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A C. elegans genetic-interaction network built by combining gene mutants and knockdowns is the largest animal network to date, revealing redundancy among functional modules and surprisingly little conservation of network connections compared to yeast.

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Journal of Biology celebrates its fifth anniversary

Journal of Biology 2007, 6:5 (29 June 2007)

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Growth control of the eukaryote cell: a systems biology study in yeast

Juan I Castrillo, Leo A Zeef, David C Hoyle, Nianshu Zhang, Andrew Hayes, David CJ Gardner, Michael J Cornell, June Petty, Luke Hakes, Leanne Wardleworth, Bharat Rash, Marie Brown, Warwick B Dunn, David Broadhurst, Kerry O'Donoghue, Svenja S Hester, Tom PJ Dunkley, Sarah R Hart, Neil Swainston, Peter Li, Simon J Gaskell, Norman W Paton, Kathryn S Lilley, Douglas B Kell, Stephen G Oliver Journal of Biology 2007, 6:4 (30 April 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The first comprehensive systems biology study on growth rate control in yeast integrates information from the transcriptome, proteome and metabolome to reveal how cell growth underlies key cellular and development processes.

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Multilevel regulation of growth rate in yeast revealed using systems biology

Arvind Ramanathan, Stuart L Schreiber Journal of Biology 2007, 6:3 (30 April 2007)

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Dosage compensation is less effective in birds than in mammals

Yuichiro Itoh, Esther Melamed, Xia Yang, Kathy Kampf, Susanna Wang, Nadir Yehya, Atila Van Nas, Kirstin Replogle, Mark R Band, David F Clayton, Eric E Schadt, Aldons J Lusis, Arthur P Arnold Journal of Biology 2007, 6:2 (22 March 2007)

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Male:female ratios of gene expression in zebra finch and chicken reveal that birds, unlike mammals, have surprisingly ineffective sex-chromosome dosage compensation mechanisms resulting in an imbalance between autosomal and sex-linked genes.

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Does gene dosage really matter?

Jennifer Graves, Christine M Disteche Journal of Biology 2007, 6:1 (22 March 2007)

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CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo

Joerg Dietrich, Ruolan Han, Yin Yang, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2006, 5:22 (30 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Chemotherapeutic agents are more toxic to cells of the central nervous system than to cancer cells when administered to mice and cultured cells, providing an explanation for adverse neurological effects of systemic chemotherapy.

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The long term effects of chemotherapy on the central nervous system

Patricia K Duffner Journal of Biology 2006, 5:21 (30 November 2006)

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High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry

Claude Lechene, Francois Hillion, Greg McMahon, Douglas Benson, Alan M Kleinfeld, J Patrick Kampf, Daniel Distel, Yvette Luyten, Joseph Bonventre, Dirk Hentschel, Kwon Park, Susumu Ito, Martin Schwartz, Gilles Benichou, Georges Slodzian Journal of Biology 2006, 5:20 (5 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

For the first time it is possible to image and quantify at nanometer resolution biological samples labeled with stable isotopes, using multi-isotope imaging mass spectrometry, applicable to all fields of biomedical research.

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Biological imaging using secondary ions

Peter Williams Journal of Biology 2006, 5:18 (5 October 2006)

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Imaging with isotopes: high resolution and quantitation

Jonathan B Weitzman Journal of Biology 2006, 5:17 (5 October 2006)

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A quantitative analysis of the mechanism that controls body size in Manduca sexta

HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006)

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Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.

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The proximate determinants of insect size

Joseph Parker, Laura A Johnston Journal of Biology 2006, 5:15 (2 August 2006)

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Distinct functions for ERKs?

Alison C Lloyd Journal of Biology 2006, 5:13 (19 July 2006)

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Dimerization in protein kinase signaling

Steven Pelech Journal of Biology 2006, 5:12 (19 July 2006)

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ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially

Chiara Vantaggiato, Ivan Formentini, Attilio Bondanza, Chiara Bonini, Luigi Naldini, Riccardo Brambilla Journal of Biology 2006, 5:14 (28 June 2006)

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The mitogen-activated protein kinases ERK1 and ERK2 have unexpectedly independent roles in normal and malignant Ras-dependent cell proliferation; ERK2 controls normal cell proliferation whereas ERK1 antagonizes ERK2 activity.

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Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

Teresa Reguly, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Gary C Hon, Chad L Myers, Ainslie Parsons, Helena Friesen, Rose Oughtred, Amy Tong, Chris Stark, Yuen Ho, David Botstein, Brenda Andrews, Charles Boone, Olga G Troyanskya, Trey Ideker, Kara Dolinski, Nizar N Batada, Mike Tyers Journal of Biology 2006, 5:11 (8 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A new literature-based yeast database documents over 33,000 biological interactions, manually curated from the primary literature, and provides an invaluable resource to benchmark high-throughput methods in the study of complex networks.

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The interaction map of yeast: terra incognita?

Joe Mellor, Charles DeLisi Journal of Biology 2006, 5:10 (8 June 2006)

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The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans

Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.

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Regulators of kinesin involved in polarized trafficking and axon outgrowth

Shuo Luo, Michael L Nonet Journal of Biology 2006, 5:8 (25 May 2006)

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Building bridges with astrocytes for spinal cord repair

Robert H Miller Journal of Biology 2006, 5:6 (9 May 2006)

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Astrocytes derived from glial-restricted precursors promote spinal cord repair

Jeannette E Davies, Carol Huang, Christoph Proschel, Mark Noble, Margot Mayer-Proschel, Stephen JA Davies Journal of Biology 2006, 5:7 (27 April 2006)

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Significantly better spinal cord repair in rats results from transplanting specific pre-differentiated cells, cultured to become immature neural-support cells, than from transplanting undifferentiated embryonic stem cells.

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Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function

Owain R Millington, Caterina Di Lorenzo, R Phillips, Paul Garside, James M Brewer Journal of Biology 2006, 5:5 (12 April 2006)

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Hemozoin pigment, released during malarial infection, is now known to cause dendritic cell failure and subsequent host immunosupression, explaining why people with malaria become prone to infection and respond poorly to vaccines.

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Malaria pigment paralyzes dendritic cells

Britta C Urban, Stephen Todryk Journal of Biology 2006, 5:4 (12 April 2006)

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Global analysis of X-chromosome dosage compensation

Vaijayanti Gupta, Michael Parisi, David Sturgill, Rachel Nuttall, Michael Doctolero, Olga K Dudko, James D Malley, P Scott Eastman, Brian Oliver Journal of Biology 2006, 5:3 (16 February 2006)

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In Drosophila germ cells, X chromosome genes are upregulated to balance their expression with that of autosomes; the same happens in somatic cells of mice and nematodes.

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A balancing act between the X chromosome and the autosomes

Mimi K Cheng, Christine M Disteche Journal of Biology 2006, 5:2 (16 February 2006)

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Getting the right dose of sex (chromosomes)

Jonathan B Weitzman Journal of Biology 2006, 5:1 (16 February 2006)

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Recycling signals in the neural crest

Lisa A Taneyhill, Marianne Bronner-Fraser Journal of Biology 2006, 4:10 (9 January 2006)

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Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells

Lars M Ittner, Heiko Wurdak, Kerstin Schwerdtfeger, Thomas Kunz, Fabian Ille, Per Leveen, Tord A Hjalt, Ueli Suter, Stefan Karlsson, Farhad Hafezi, Walter Born, Lukas Sommer Journal of Biology 2005, 4:11 (14 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Important structures in developing mouse eyes originate from neural crest cells controlled by TGFbeta signals from the lens, providing insight into human conditions that results in glaucoma and blindness.

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