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Research article   Open Access Highly Accessed

Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs

Andrey V Zavialov, Vasili V Hauryliuk, Måns Ehrenberg Journal of Biology 2005, 4:9 (27 June 2005)

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Movement in ribosome translocation

Christopher S Fraser, John WB Hershey Journal of Biology 2005, 4:8 (27 June 2005)

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The GTPase switch in ribosomal translocation

Pete Moore Journal of Biology 2005, 4:7 (27 June 2005)

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Untangling the web of functional and physical interactions in yeast

Markus J Herrgård, Bernhard Ø Palsson Journal of Biology 2005, 4:5 (8 June 2005)

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Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network

Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone, Frederick P Roth Journal of Biology 2005, 4:6 (1 June 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The multiple complex biological interactions in a yeast cell can be mapped in a simple graphical form, enhancing our understanding of the networks of interaction by which components of a cell influence one another.

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A road map of yeast interactions

Jonathan B Weitzman Journal of Biology 2005, 4:4 (1 June 2005)

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Dishevelled and Wnt signaling: is the nucleus the final frontier?

Raymond Habas, Igor B Dawid Journal of Biology 2005, 4:2 (17 February 2005)

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Dishevelled nuclear shuttling

Jonathan B Weitzman Journal of Biology 2005, 4:1 (16 February 2005)

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Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

Keiji Itoh, Barbara K Brott, Gyu-Un Bae, Marianne J Ratcliffe, Sergei Y Sokol Journal of Biology 2005, 4:3 (15 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, doesn't only function in the cytoplasm and at the cell membrane, but must be imported into the nucleus to perform at least one key aspect of its function.

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All systems GO for understanding mouse gene function

Chris Holmes, Steve DM Brown Journal of Biology 2004, 3:20 (17 December 2004)

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The functional landscape of mouse gene expression

Wen Zhang, Quaid D Morris, Richard Chang, Ofer Shai, Malina A Bakowski, Nicholas Mitsakakis, Naveed Mohammad, Mark D Robinson, Ralph Zirngibl, Eszter Somogyi, Nancy Laurin, Eftekhar Eftekharpour, Eric Sat, Jörg Grigull, Qun Pan, Wen-Tao Peng, Nevan Krogan, Jack Greenblatt, Michael Fehlings, Derek van der Kooy, Jane Aubin, Benoit G Bruneau, Janet Rossant, Benjamin J Blencowe, Brendan J Frey, Timothy R Hughes Journal of Biology 2004, 3:21 (6 December 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Gene function in mammals can be quickly and reliably predicted using a quantitative analysis of tissue-specific patterns of RNA expression.

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Co-regulation of mouse genes predicts function

Jonathan B Weitzman Journal of Biology 2004, 3:19 (6 December 2004)

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Editorial   Open Access

Editorial

Journal of Biology 2004, 3:12 (20 October 2004)

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Who's driving the centromere?

Gregory P Copenhaver Journal of Biology 2004, 3:17 (11 October 2004)

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The curious world of apoptotic cell clearance

Jonathan B Weitzman Journal of Biology 2004, 3:13 (29 September 2004)

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Hide and seek: the secret identity of the phosphatidylserine receptor

Patrick Williamson, Robert A Schlegel Journal of Biology 2004, 3:14 (23 September 2004)

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Adaptive evolution of centromere proteins in plants and animals

Paul B Talbert, Terri D Bryson, Steven Henikoff Journal of Biology 2004, 3:18 (31 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Centromere-binding proteins, like the DNA they bind, are rapidly evolving, a remarkable finding given that they are essential for every cell division and so would be expected to be very highly conserved.

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Making sense of centromeres

Pete Moore Journal of Biology 2004, 3:16 (31 August 2004)

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The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

Jens Böse, Achim D Gruber, Laura Helming, Stefanie Schiebe, Ivonne Wegener, Martin Hafner, Marianne Beales, Frank Köntgen, Andreas Lengeling Journal of Biology 2004, 3:15 (23 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The phosphatidylserine receptor is not needed for the recognition of dying cells as previously thought, and instead plays a role in the differentiation of a wide range of tissues during embryogenesis.

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Wnt signaling and the developmental fate of lung cells

Julie Clayton Journal of Biology 2004, 3:9 (28 June 2004)

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Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm

Tadashi Okubo, Brigid LM Hogan Journal of Biology 2004, 3:11 (8 June 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Abnormal activation of the Wnt signaling pathway can alter the fate of progenitor cells that normally generate the lung, causing them to create gut cells instead.

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Intestine in the lung

Jonathan MW Slack Journal of Biology 2004, 3:10 (8 June 2004)

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Editorial   Open Access

Editorial

Journal of Biology 2004, 3:5 (7 May 2004)

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The hydrodynamics of dolphin drafting

Daniel Weihs Journal of Biology 2004, 3:8 (4 May 2004)

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Models of the hydrodynamic forces between two swimming dolphins show that baby dolphins keep up with their more powerful mothers by getting an almost energetically "free ride" in their slipstream.

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Hitching a lift hydrodynamically - in swimming, flying and cycling

R McNeill Alexander Journal of Biology 2004, 3:7 (4 May 2004)

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Examining dolphin hydrodynamics provides clues to calf-loss during tuna fishing

Pete Moore Journal of Biology 2004, 3:6 (4 May 2004)

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Editorial

Theodora Bloom Journal of Biology 2004, 3:1 (16 January 2004)

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Bending out and breaking away: host-cell accomplices in retroviral escape

Melvyn W Yap, Jonathan P Stoye Journal of Biology 2003, 3:3 (19 December 2003)

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Budding viral hijackers co-opt the endocytic machinery to make a getaway

Diane Martindale Journal of Biology 2003, 3:2 (19 December 2003)

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Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production

Margaret Q Wang, Wankee Kim, Guangxia Gao, Ted A Torrey, Herbert C Morse, Pietro De Camilli, Stephen P Goff Journal of Biology 2003, 3:4 (4 December 2003)

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RNAi and the shape of things to come

Jonathan B Weitzman Journal of Biology 2003, 2:23 (4 November 2003)

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Connecting LKB1 and AMPK links metabolism with cancer

Pete Moore Journal of Biology 2003, 2:24 (29 October 2003)

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At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

John M Kyriakis Journal of Biology 2003, 2:26 (22 October 2003)

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Editorial

Theodora Bloom Journal of Biology 2003, 2:15 (15 October 2003)

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A functional genomic analysis of cell morphology using RNA interference

AA Kiger, B Baum, S Jones, MR Jones, A Coulson, C Echeverri, N Perrimon Journal of Biology 2003, 2:27 (1 October 2003)

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Functional genomics of cell morphology using RNA interference: pick your style, broad or deep

Thomas D Pollard Journal of Biology 2003, 2:25 (1 October 2003)

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Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Simon A Hawley, Jérôme Boudeau, Jennifer L Reid, Kirsty J Mustard, Lina Udd, Tomi P Mäkelä, Dario R Alessi, D Grahame Hardie Journal of Biology 2003, 2:28 (24 September 2003)

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Identifying new T-cell regulators

Diane Martindale Journal of Biology 2003, 2:17 (22 September 2003)

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Systematic identification of regulatory proteins critical for T-cell activation

Peter Chu, Jorge Pardo, Haoran Zhao, Connie C Li, Erlina Pali, Mary M Shen, Kunbin Qu, Simon X Yu, Betty CB Huang, Peiwen Yu, Esteban S Masuda, Susan M Molineaux, Frank Kolbinger, Gregorio Aversa, Jan de Vries, Donald G Payan, X Charlene Liao Journal of Biology 2003, 2:21 (15 September 2003)

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Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors

Thomas P Neufeld Journal of Biology 2003, 2:18 (11 September 2003)

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Controlling how many cells make a fly

Pete Moore Journal of Biology 2003, 2:16 (21 August 2003)

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The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

Martin A Jünger, Felix Rintelen, Hugo Stocker, Jonathan D Wasserman, Mátyás Végh, Thomas Radimerski, Michael E Greenberg, Ernst Hafen Journal of Biology 2003, 2:20 (7 August 2003)

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Stress, sex and evolution

Pete Moore Journal of Biology 2003, 2:10 (27 June 2003)

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Environmental stress and the effects of mutation

Santiago F Elena, J Arjan GM de Visser Journal of Biology 2003, 2:12 (26 June 2003)

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Tracking evolution's footprints in the genome

Jonathan B Weitzman Journal of Biology 2003, 2:9 (23 June 2003)

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Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements

Zhaolei Zhang, Mark Gerstein Journal of Biology 2003, 2:11 (6 June 2003)

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Environmental stresses can alleviate the average deleterious effect of mutations

Roy Kishony, Stanislas Leibler Journal of Biology 2003, 2:14 (29 May 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment | F1000 Biology

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Identification of conserved regulatory elements by comparative genome analysis

Boris Lenhard, Albin Sandelin, Luis Mendoza, Pär Engström, Niclas Jareborg, Wyeth W Wasserman Journal of Biology 2003, 2:13 (22 May 2003)

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Editorial

Theodora Bloom Journal of Biology 2003, 2:1 (2 May 2003)

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Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression

Ian Conlon, Martin Raff Journal of Biology 2003, 2:7 (24 April 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 4 comments | F1000 Biology

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