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Stage debut for the elusive Drosophila insulin-like growth factor binding protein

Nazif Alic, Linda Partridge Journal of Biology 2008, 7:18 (7 July 2008)

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Making the jump: new insights into the mechanism of trans-translation

Jacek Wower, Iwona K Wower, Christian Zwieb Journal of Biology 2008, 7:17 (30 June 2008)

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Zoological detective stories: the case of the facetotectan crustacean life cycle

Gerhard Scholtz Journal of Biology 2008, 7:16 (26 June 2008)

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Spatially patterned gradients of synaptic connectivity are established early in the developing retina

Susana Cohen-Cory Journal of Biology 2008, 7:15 (9 June 2008)

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Process rather than pattern: finding pine needles in the coevolutionary haystack

David R Nash Journal of Biology 2008, 7:14 (28 May 2008)

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Colugos: obscure mammals glide into the evolutionary limelight

Robert D Martin Journal of Biology 2008, 7:13 (1 May 2008)

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Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system

Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2008, 7:12 (22 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

The chemotherapy drug, 5-fluorouracil, causes delayed degeneration in the central nervous system of animals, a newly identified type of damage that helps explain the cognitive defects or `chemobrain` symptoms associated with cancer treatment.

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How chemotherapy damages the central nervous system

Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

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Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.

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Small changes, big results: evolution of morphological discontinuity in mammals

Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008)

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A Caenorhabditis elegans genetic-interaction map wiggles into view

Kristin C Gunsalus Journal of Biology 2008, 7:8 (7 March 2008)

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Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?

Nicolas Vodovar, François Schweisguth Journal of Biology 2008, 7:7 (28 February 2008)

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Reasons for breast cancer heterogeneity

François Bertucci, Daniel Birnbaum Journal of Biology 2008, 7:6 (22 February 2008)

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Great exaptations

Kathleen H Burns, Jef D Boeke Journal of Biology 2008, 7:5 (15 February 2008)

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Semaphorins deployed to repel cell migrants at spinal cord borders

Sophie Chauvet, Geneviève Rougon Journal of Biology 2008, 7:4 (7 February 2008)

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Electrical protein detection in cell lysates using high-density peptide-aptamer microarrays

David Evans, Steven Johnson, Sophie Laurenson, A Giles Davies, Paul Ko Ferrigno, Christoph Wälti Journal of Biology 2008, 7:3 (31 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Specific detection of protein isoforms in whole cell lysates is now more efficient with the arrival of a label-free electronic sensing system consisting of immobilized peptide aptamers on individual gold electrodes at the micron scale.

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The eleven-year switch of peptide aptamers

Pierre Colas Journal of Biology 2008, 7:2 (31 January 2008)

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Metabolic reconfiguration is a regulated response to oxidative stress

Chris M Grant Journal of Biology 2008, 7:1 (25 January 2008)

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Cryptic biodiversity in a changing world

Luciano B Beheregaray, Adalgisa Caccone Journal of Biology 2007, 6:9 (21 December 2007)

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Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach, Sylvia Krobitsch Journal of Biology 2007, 6:10 (21 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Yeast and C. elegans share a conserved cellular mechanism that counteracts the fatal consequences of oxidative stress by enabling the redirection of metabolic flux from glycolysis to the pentose phosphate pathway.

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Landscape genetics goes to sea

Michael Hansen, Jakob Hemmer-Hansen Journal of Biology 2007, 6:6 (16 November 2007)

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A global analysis of genetic interactions in Caenorhabditis elegans

Alexandra B Byrne, Matthew T Weirauch, Victoria Wong, Martina Koeva, Scott J Dixon, Joshua M Stuart, Peter J Roy Journal of Biology 2007, 6:8 (26 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A C. elegans genetic-interaction network built by combining gene mutants and knockdowns is the largest animal network to date, revealing redundancy among functional modules and surprisingly little conservation of network connections compared to yeast.

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Journal of Biology celebrates its fifth anniversary

Journal of Biology 2007, 6:5 (29 June 2007)

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Growth control of the eukaryote cell: a systems biology study in yeast

Juan I Castrillo, Leo A Zeef, David C Hoyle, Nianshu Zhang, Andrew Hayes, David CJ Gardner, Michael J Cornell, June Petty, Luke Hakes, Leanne Wardleworth, Bharat Rash, Marie Brown, Warwick B Dunn, David Broadhurst, Kerry O'Donoghue, Svenja S Hester, Tom PJ Dunkley, Sarah R Hart, Neil Swainston, Peter Li, Simon J Gaskell, Norman W Paton, Kathryn S Lilley, Douglas B Kell, Stephen G Oliver Journal of Biology 2007, 6:4 (30 April 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The first comprehensive systems biology study on growth rate control in yeast integrates information from the transcriptome, proteome and metabolome to reveal how cell growth underlies key cellular and development processes.

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Multilevel regulation of growth rate in yeast revealed using systems biology

Arvind Ramanathan, Stuart L Schreiber Journal of Biology 2007, 6:3 (30 April 2007)

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