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Research article   Open Access Highly Accessed

Dosage compensation is less effective in birds than in mammals

Yuichiro Itoh, Esther Melamed, Xia Yang, Kathy Kampf, Susanna Wang, Nadir Yehya, Atila Van Nas, Kirstin Replogle, Mark R Band, David F Clayton, Eric E Schadt, Aldons J Lusis, Arthur P Arnold Journal of Biology 2007, 6:2 (22 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Male:female ratios of gene expression in zebra finch and chicken reveal that birds, unlike mammals, have surprisingly ineffective sex-chromosome dosage compensation mechanisms resulting in an imbalance between autosomal and sex-linked genes.

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Does gene dosage really matter?

Jennifer Graves, Christine M Disteche Journal of Biology 2007, 6:1 (22 March 2007)

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Research article   Open Access Highly Accessed

CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo

Joerg Dietrich, Ruolan Han, Yin Yang, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2006, 5:22 (30 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Chemotherapeutic agents are more toxic to cells of the central nervous system than to cancer cells when administered to mice and cultured cells, providing an explanation for adverse neurological effects of systemic chemotherapy.

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The long term effects of chemotherapy on the central nervous system

Patricia K Duffner Journal of Biology 2006, 5:21 (30 November 2006)

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Research article   Open Access Highly Accessed

High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry

Claude Lechene, Francois Hillion, Greg McMahon, Douglas Benson, Alan M Kleinfeld, J Patrick Kampf, Daniel Distel, Yvette Luyten, Joseph Bonventre, Dirk Hentschel, Kwon Park, Susumu Ito, Martin Schwartz, Gilles Benichou, Georges Slodzian Journal of Biology 2006, 5:20 (5 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

For the first time it is possible to image and quantify at nanometer resolution biological samples labeled with stable isotopes, using multi-isotope imaging mass spectrometry, applicable to all fields of biomedical research.

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Biological imaging using secondary ions

Peter Williams Journal of Biology 2006, 5:18 (5 October 2006)

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Imaging with isotopes: high resolution and quantitation

Jonathan B Weitzman Journal of Biology 2006, 5:17 (5 October 2006)

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Research article   Open Access Highly Accessed

A quantitative analysis of the mechanism that controls body size in Manduca sexta

HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.

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The proximate determinants of insect size

Joseph Parker, Laura A Johnston Journal of Biology 2006, 5:15 (2 August 2006)

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Distinct functions for ERKs?

Alison C Lloyd Journal of Biology 2006, 5:13 (19 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

Comment   Free Highly Accessed

Dimerization in protein kinase signaling

Steven Pelech Journal of Biology 2006, 5:12 (19 July 2006)

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Research article   Open Access Highly Accessed

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially

Chiara Vantaggiato, Ivan Formentini, Attilio Bondanza, Chiara Bonini, Luigi Naldini, Riccardo Brambilla Journal of Biology 2006, 5:14 (28 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The mitogen-activated protein kinases ERK1 and ERK2 have unexpectedly independent roles in normal and malignant Ras-dependent cell proliferation; ERK2 controls normal cell proliferation whereas ERK1 antagonizes ERK2 activity.

Research article   Open Access Highly Accessed

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

Teresa Reguly, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Gary C Hon, Chad L Myers, Ainslie Parsons, Helena Friesen, Rose Oughtred, Amy Tong, Chris Stark, Yuen Ho, David Botstein, Brenda Andrews, Charles Boone, Olga G Troyanskya, Trey Ideker, Kara Dolinski, Nizar N Batada, Mike Tyers Journal of Biology 2006, 5:11 (8 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A new literature-based yeast database documents over 33,000 biological interactions, manually curated from the primary literature, and provides an invaluable resource to benchmark high-throughput methods in the study of complex networks.

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The interaction map of yeast: terra incognita?

Joe Mellor, Charles DeLisi Journal of Biology 2006, 5:10 (8 June 2006)

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Research article   Open Access Highly Accessed

The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans

Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.

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Regulators of kinesin involved in polarized trafficking and axon outgrowth

Shuo Luo, Michael L Nonet Journal of Biology 2006, 5:8 (25 May 2006)

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Building bridges with astrocytes for spinal cord repair

Robert H Miller Journal of Biology 2006, 5:6 (9 May 2006)

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Research article   Open Access Highly Accessed

Astrocytes derived from glial-restricted precursors promote spinal cord repair

Jeannette E Davies, Carol Huang, Christoph Proschel, Mark Noble, Margot Mayer-Proschel, Stephen JA Davies Journal of Biology 2006, 5:7 (27 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Significantly better spinal cord repair in rats results from transplanting specific pre-differentiated cells, cultured to become immature neural-support cells, than from transplanting undifferentiated embryonic stem cells.

Research article   Open Access Highly Accessed

Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function

Owain R Millington, Caterina Di Lorenzo, R Phillips, Paul Garside, James M Brewer Journal of Biology 2006, 5:5 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Hemozoin pigment, released during malarial infection, is now known to cause dendritic cell failure and subsequent host immunosupression, explaining why people with malaria become prone to infection and respond poorly to vaccines.

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Malaria pigment paralyzes dendritic cells

Britta C Urban, Stephen Todryk Journal of Biology 2006, 5:4 (12 April 2006)

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Research article   Open Access Highly Accessed

Global analysis of X-chromosome dosage compensation

Vaijayanti Gupta, Michael Parisi, David Sturgill, Rachel Nuttall, Michael Doctolero, Olga K Dudko, James D Malley, P Scott Eastman, Brian Oliver Journal of Biology 2006, 5:3 (16 February 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

In Drosophila germ cells, X chromosome genes are upregulated to balance their expression with that of autosomes; the same happens in somatic cells of mice and nematodes.

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A balancing act between the X chromosome and the autosomes

Mimi K Cheng, Christine M Disteche Journal of Biology 2006, 5:2 (16 February 2006)

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Getting the right dose of sex (chromosomes)

Jonathan B Weitzman Journal of Biology 2006, 5:1 (16 February 2006)

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Recycling signals in the neural crest

Lisa A Taneyhill, Marianne Bronner-Fraser Journal of Biology 2006, 4:10 (9 January 2006)

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Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells

Lars M Ittner, Heiko Wurdak, Kerstin Schwerdtfeger, Thomas Kunz, Fabian Ille, Per Leveen, Tord A Hjalt, Ueli Suter, Stefan Karlsson, Farhad Hafezi, Walter Born, Lukas Sommer Journal of Biology 2005, 4:11 (14 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Important structures in developing mouse eyes originate from neural crest cells controlled by TGFbeta signals from the lens, providing insight into human conditions that results in glaucoma and blindness.

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