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	1. 955 Accesses	Comment Are we training pit bulls to review our manuscripts? Virginia Walbot Journal of Biology 2009, 8:24 (9 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| Editor’s summary Virginia Walbot accepts some of the blame for remorselessly negative reviewers, and suggests a training program for graduate students and post docs that will deliver a fairer assessment of manuscripts.
	2. 571 Accesses	Minireview Small changes, big results: evolution of morphological discontinuity in mammals Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008) Abstract \| Full text \| PDF \| PubMed
	3. 544 Accesses	Minireview Music, memory and emotion Lutz Jäncke Journal of Biology 2008, 7:21 (8 August 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	4. 439 Accesses	Research article Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2008, 7:12 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary The chemotherapy drug, 5-fluorouracil, causes delayed degeneration in the central nervous system of animals, a newly identified type of damage that helps explain the cognitive defects or `chemobrain` symptoms associated with cancer treatment.
	5. 435 Accesses	Opinion Top dogs: wolf domestication and wealth Carlos A Driscoll, David W Macdonald Journal of Biology 2010, 9:10 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on a phylogeographic analysis in BMC Biology that supports a Middle Eastern origin of small dogs, Driscoll and Macdonald speculate on the implications of wolf domestication and size reduction occurring at a time of transition between hunter-gatherer and sedentary societies.
	6. 398 Accesses	Research article Growth control of the eukaryote cell: a systems biology study in yeast Juan I Castrillo, Leo A Zeef, David C Hoyle, Nianshu Zhang, Andrew Hayes, David CJ Gardner, Michael J Cornell, June Petty, Luke Hakes, Leanne Wardleworth, Bharat Rash, Marie Brown, Warwick B Dunn, David Broadhurst, Kerry O'Donoghue, Svenja S Hester, Tom PJ Dunkley, Sarah R Hart, Neil Swainston, Peter Li, Simon J Gaskell, Norman W Paton, Kathryn S Lilley, Douglas B Kell, Stephen G Oliver Journal of Biology 2007, 6:4 (30 April 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The first comprehensive systems biology study on growth rate control in yeast integrates information from the transcriptome, proteome and metabolome to reveal how cell growth underlies key cellular and development processes.
	7. 394 Accesses	Research article Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae Teresa Reguly, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Gary C Hon, Chad L Myers, Ainslie Parsons, Helena Friesen, Rose Oughtred, Amy Tong, Chris Stark, Yuen Ho, David Botstein, Brenda Andrews, Charles Boone, Olga G Troyanskya, Trey Ideker, Kara Dolinski, Nizar N Batada, Mike Tyers Journal of Biology 2006, 5:11 (8 June 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new literature-based yeast database documents over 33,000 biological interactions, manually curated from the primary literature, and provides an invaluable resource to benchmark high-throughput methods in the study of complex networks.
	8. 344 Accesses	Research article The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling Martin A Jünger, Felix Rintelen, Hugo Stocker, Jonathan D Wasserman, Mátyás Végh, Thomas Radimerski, Michael E Greenberg, Ernst Hafen Journal of Biology 2003, 2:20 (7 August 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	9. 347 Accesses	Comment Open access to the scientific journal literature Peter Suber Journal of Biology 2002, 1:3 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	10. 326 Accesses	Minireview Parasite immunomodulation and polymorphisms of the immune system Rick M Maizels Journal of Biology 2009, 8:62 (5 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rick Maizels discusses a recent paper in BMC Biology on wild mammals that lend support to the hygiene hypothesis, and explains why genetic variants that reduce parasite-induced immunosuppression are associated with an increase in allergic reactions.
	11. 324 Accesses	Research article Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach, Sylvia Krobitsch Journal of Biology 2007, 6:10 (21 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Yeast and C. elegans share a conserved cellular mechanism that counteracts the fatal consequences of oxidative stress by enabling the redirection of metabolic flux from glycolysis to the pentose phosphate pathway.
	12. 316 Accesses	Research article Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila Silvia Gluderer, Erich Brunner, Markus Germann, Virginija Jovaisaite, Changqing Li, Cyrill A Rentsch, Ernst Hafen, Hugo Stocker Journal of Biology 2010, 9:9 (11 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stocker and colleagues identify and analyze a growth-promoting complex in Drosophila, formed between the putative transcription factor BunA, for which human homologs can functionally substitute, and the adaptor protein Madm.
	13. 312 Accesses	Minireview Making progress in genetic kin recognition among vertebrates Jane L Hurst, Robert J Beynon Journal of Biology 2010, 9:13 (17 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Highlighting recent research in BMC Evolutionary Biology that analyzes the scent profiles of ring-tailed lemurs in relation to their genetic distance, Hurst and Benyon discuss recent progress and remaining challenges in deciphering how vertebrates recognise kin by their smell.
	14. 304 Accesses	Minireview The origin and evolution of lactation Anthony V Capuco, R Michael Akers Journal of Biology 2009, 8:37 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Capuco and Akers review the biology of lactation and discuss a new report in Genome Biology that compares the bovine genome with six other mammalian genomes to study how lactation and its regulation evolved.
	15. 301 Accesses	Research article Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade Simon A Hawley, Jérôme Boudeau, Jennifer L Reid, Kirsty J Mustard, Lina Udd, Tomi P Mäkelä, Dario R Alessi, D Grahame Hardie Journal of Biology 2003, 2:28 (24 September 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	16. 288 Accesses	Research article The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.
	17. 283 Accesses	Research article Bridge helix and trigger loop perturbations generate superactive RNA polymerases Lin Tan, Simone Wiesler, Dominika Trzaska, Hannah C Carney, Robert OJ Weinzierl Journal of Biology 2008, 7:40 (2 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mutations targeted to key functional areas of RNA polymerases can generate superactive enzymes that suggest how conformational changes in specialized domains of the enzyme contribute to the catalytic cycle.
	18. 274 Accesses	Research article Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists Maria Frank-Kamenetsky, Xiaoyan M Zhang, Steve Bottega, Oivin Guicherit, Hynek Wichterle, Henryk Dudek, David Bumcrot, Frank Y Wang, Simon Jones, Janine Shulok, Lee L Rubin, Jeffery A Porter Journal of Biology 2002, 1:10 (6 November 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Characterization of small-molecule agonists and antagonists of the Hedgehog signaling pathway reveals that these candidate therapeutics act at the level of the pathway activator Smoothened, which may normally be regulated by an endogenous small molecule.
	19. 271 Accesses	Minireview Acoel and platyhelminth models for stem-cell research Alexandra E Bely, James M Sikes Journal of Biology 2010, 9:14 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The bodies of platyhelminth and acoel worms are continually renewed from large pools of somatic stem cells. Bely and Sikes discuss their consequent attractiveness for stem cell research, and how recent studies, including one in BMC Developmental Biology, reveal aspects of the cellular dynamics and molecular basis of stem-cell function in these animals.
	20. 271 Accesses	Minireview Adaptations of proteins to cellular and subcellular pH Bertrand Garcia-Moreno Journal of Biology 2009, 8:98 (2 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Protein function and stability are acutely sensitive to pH, which varies in different subcellular compartments. Garcia-Moreno discusses research recently reported in BMC Biology suggesting that adaptation to different compartments is reflected in charge distribution.
	21. 270 Accesses	Minireview Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'? Maria Grazia Lampugnani Journal of Biology 2010, 9:16 (8 April 2010) Abstract \| Full text \| PDF \| PubMed
	22. 264 Accesses	Minireview Timing the first human migration into eastern Asia Roscoe Stanyon, Marco Sazzini, Donata Luiselli Journal of Biology 2009, 8:18 (6 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments
	23. 261 Accesses	Research article High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry Claude Lechene, Francois Hillion, Greg McMahon, Douglas Benson, Alan M Kleinfeld, J Patrick Kampf, Daniel Distel, Yvette Luyten, Joseph Bonventre, Dirk Hentschel, Kwon Park, Susumu Ito, Martin Schwartz, Gilles Benichou, Georges Slodzian Journal of Biology 2006, 5:20 (5 October 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary For the first time it is possible to image and quantify at nanometer resolution biological samples labeled with stable isotopes, using multi-isotope imaging mass spectrometry, applicable to all fields of biomedical research.
	24. 259 Accesses	Research article Conservation of core gene expression in vertebrate tissues Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.
	25. 259 Accesses	Minireview The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.