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	1. 67103 Accesses	Research article Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells Lars M Ittner, Heiko Wurdak, Kerstin Schwerdtfeger, Thomas Kunz, Fabian Ille, Per Leveen, Tord A Hjalt, Ueli Suter, Stefan Karlsson, Farhad Hafezi, Walter Born, Lukas Sommer Journal of Biology 2005, 4:11 (14 December 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Important structures in developing mouse eyes originate from neural crest cells controlled by TGFbeta signals from the lens, providing insight into human conditions that results in glaucoma and blindness.
	2. 57480 Accesses	Research article A functional genomic analysis of cell morphology using RNA interference AA Kiger, B Baum, S Jones, MR Jones, A Coulson, C Echeverri, N Perrimon Journal of Biology 2003, 2:27 (1 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	3. 46781 Accesses	Comment Are we training pit bulls to review our manuscripts? Virginia Walbot Journal of Biology 2009, 8:24 (9 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| Editor’s summary Virginia Walbot accepts some of the blame for remorselessly negative reviewers, and suggests a training program for graduate students and post docs that will deliver a fairer assessment of manuscripts.
	4. 46671 Accesses	Research article The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling Martin A Jünger, Felix Rintelen, Hugo Stocker, Jonathan D Wasserman, Mátyás Végh, Thomas Radimerski, Michael E Greenberg, Ernst Hafen Journal of Biology 2003, 2:20 (7 August 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	5. 44569 Accesses	Comment Open access to the scientific journal literature Peter Suber Journal of Biology 2002, 1:3 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	6. 43969 Accesses	Research article The functional landscape of mouse gene expression Wen Zhang, Quaid D Morris, Richard Chang, Ofer Shai, Malina A Bakowski, Nicholas Mitsakakis, Naveed Mohammad, Mark D Robinson, Ralph Zirngibl, Eszter Somogyi, Nancy Laurin, Eftekhar Eftekharpour, Eric Sat, Jörg Grigull, Qun Pan, Wen-Tao Peng, Nevan Krogan, Jack Greenblatt, Michael Fehlings, Derek van der Kooy, Jane Aubin, Benoit G Bruneau, Janet Rossant, Benjamin J Blencowe, Brendan J Frey, Timothy R Hughes Journal of Biology 2004, 3:21 (6 December 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Gene function in mammals can be quickly and reliably predicted using a quantitative analysis of tissue-specific patterns of RNA expression.
	7. 41043 Accesses	Research article Growth control of the eukaryote cell: a systems biology study in yeast Juan I Castrillo, Leo A Zeef, David C Hoyle, Nianshu Zhang, Andrew Hayes, David CJ Gardner, Michael J Cornell, June Petty, Luke Hakes, Leanne Wardleworth, Bharat Rash, Marie Brown, Warwick B Dunn, David Broadhurst, Kerry O'Donoghue, Svenja S Hester, Tom PJ Dunkley, Sarah R Hart, Neil Swainston, Peter Li, Simon J Gaskell, Norman W Paton, Kathryn S Lilley, Douglas B Kell, Stephen G Oliver Journal of Biology 2007, 6:4 (30 April 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The first comprehensive systems biology study on growth rate control in yeast integrates information from the transcriptome, proteome and metabolome to reveal how cell growth underlies key cellular and development processes.
	8. 39987 Accesses	Research article The hydrodynamics of dolphin drafting Daniel Weihs Journal of Biology 2004, 3:8 (4 May 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Models of the hydrodynamic forces between two swimming dolphins show that baby dolphins keep up with their more powerful mothers by getting an almost energetically "free ride" in their slipstream.
	9. 37334 Accesses	Research article Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists Maria Frank-Kamenetsky, Xiaoyan M Zhang, Steve Bottega, Oivin Guicherit, Hynek Wichterle, Henryk Dudek, David Bumcrot, Frank Y Wang, Simon Jones, Janine Shulok, Lee L Rubin, Jeffery A Porter Journal of Biology 2002, 1:10 (6 November 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Characterization of small-molecule agonists and antagonists of the Hedgehog signaling pathway reveals that these candidate therapeutics act at the level of the pathway activator Smoothened, which may normally be regulated by an endogenous small molecule.
	10. 36959 Accesses	Research article Evidence for large domains of similarly expressed genes in the Drosophila genome Paul T Spellman, Gerald M Rubin Journal of Biology 2002, 1:5 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	11. 34955 Accesses	Research article Adaptive evolution of centromere proteins in plants and animals Paul B Talbert, Terri D Bryson, Steven Henikoff Journal of Biology 2004, 3:18 (31 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Centromere-binding proteins, like the DNA they bind, are rapidly evolving, a remarkable finding given that they are essential for every cell division and so would be expected to be very highly conserved.
	12. 33345 Accesses	Research article CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo Joerg Dietrich, Ruolan Han, Yin Yang, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2006, 5:22 (30 November 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Chemotherapeutic agents are more toxic to cells of the central nervous system than to cancer cells when administered to mice and cultured cells, providing an explanation for adverse neurological effects of systemic chemotherapy.
	13. 33047 Accesses	Research article Identification of conserved regulatory elements by comparative genome analysis Boris Lenhard, Albin Sandelin, Luis Mendoza, Pär Engström, Niclas Jareborg, Wyeth W Wasserman Journal of Biology 2003, 2:13 (22 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	14. 31946 Accesses	Research article Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae Teresa Reguly, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Gary C Hon, Chad L Myers, Ainslie Parsons, Helena Friesen, Rose Oughtred, Amy Tong, Chris Stark, Yuen Ho, David Botstein, Brenda Andrews, Charles Boone, Olga G Troyanskya, Trey Ideker, Kara Dolinski, Nizar N Batada, Mike Tyers Journal of Biology 2006, 5:11 (8 June 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new literature-based yeast database documents over 33,000 biological interactions, manually curated from the primary literature, and provides an invaluable resource to benchmark high-throughput methods in the study of complex networks.
	15. 31118 Accesses	Research article The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal Jens Böse, Achim D Gruber, Laura Helming, Stefanie Schiebe, Ivonne Wegener, Martin Hafner, Marianne Beales, Frank Köntgen, Andreas Lengeling Journal of Biology 2004, 3:15 (23 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The phosphatidylserine receptor is not needed for the recognition of dying cells as previously thought, and instead plays a role in the differentiation of a wide range of tissues during embryogenesis.
	16. 30951 Accesses	Research article High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry Claude Lechene, Francois Hillion, Greg McMahon, Douglas Benson, Alan M Kleinfeld, J Patrick Kampf, Daniel Distel, Yvette Luyten, Joseph Bonventre, Dirk Hentschel, Kwon Park, Susumu Ito, Martin Schwartz, Gilles Benichou, Georges Slodzian Journal of Biology 2006, 5:20 (5 October 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary For the first time it is possible to image and quantify at nanometer resolution biological samples labeled with stable isotopes, using multi-isotope imaging mass spectrometry, applicable to all fields of biomedical research.
	17. 30944 Accesses	Research article Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression Ian Conlon, Martin Raff Journal of Biology 2003, 2:7 (24 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| F1000 Biology
	18. 30376 Accesses	Research article Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Pröschel, Mark Noble Journal of Biology 2008, 7:12 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary The chemotherapy drug, 5-fluorouracil, causes delayed degeneration in the central nervous system of animals, a newly identified type of damage that helps explain the cognitive defects or `chemobrain` symptoms associated with cancer treatment.
	19. 29932 Accesses	Research article Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade Simon A Hawley, Jérôme Boudeau, Jennifer L Reid, Kirsty J Mustard, Lina Udd, Tomi P Mäkelä, Dario R Alessi, D Grahame Hardie Journal of Biology 2003, 2:28 (24 September 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	20. 28373 Accesses	Minireview Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements Zhaolei Zhang, Mark Gerstein Journal of Biology 2003, 2:11 (6 June 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	21. 27856 Accesses	Research article Combined optical trapping and single-molecule fluorescence Matthew J Lang, Polly M Fordyce, Steven M Block Journal of Biology 2003, 2:6 (24 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	22. 27581 Accesses	Research article Astrocytes derived from glial-restricted precursors promote spinal cord repair Jeannette E Davies, Carol Huang, Christoph Proschel, Mark Noble, Margot Mayer-Proschel, Stephen JA Davies Journal of Biology 2006, 5:7 (27 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Significantly better spinal cord repair in rats results from transplanting specific pre-differentiated cells, cultured to become immature neural-support cells, than from transplanting undifferentiated embryonic stem cells.
	23. 27514 Accesses	Research article Systematic identification of regulatory proteins critical for T-cell activation Peter Chu, Jorge Pardo, Haoran Zhao, Connie C Li, Erlina Pali, Mary M Shen, Kunbin Qu, Simon X Yu, Betty CB Huang, Peiwen Yu, Esteban S Masuda, Susan M Molineaux, Frank Kolbinger, Gregorio Aversa, Jan de Vries, Donald G Payan, X Charlene Liao Journal of Biology 2003, 2:21 (15 September 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	24. 27112 Accesses	Research article Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm Tadashi Okubo, Brigid LM Hogan Journal of Biology 2004, 3:11 (8 June 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Abnormal activation of the Wnt signaling pathway can alter the fate of progenitor cells that normally generate the lung, causing them to create gut cells instead.
	25. 26517 Accesses	Research article Environmental stresses can alleviate the average deleterious effect of mutations Roy Kishony, Stanislas Leibler Journal of Biology 2003, 2:14 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology
	26. 26383 Accesses	Minireview Gene expression neighborhoods Brian Oliver, Michael Parisi, David Clark Journal of Biology 2002, 1:4 (1 July 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	27. 25502 Accesses	Minireview Music, memory and emotion Lutz Jäncke Journal of Biology 2008, 7:21 (8 August 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	28. 24980 Accesses	Research article ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially Chiara Vantaggiato, Ivan Formentini, Attilio Bondanza, Chiara Bonini, Luigi Naldini, Riccardo Brambilla Journal of Biology 2006, 5:14 (28 June 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The mitogen-activated protein kinases ERK1 and ERK2 have unexpectedly independent roles in normal and malignant Ras-dependent cell proliferation; ERK2 controls normal cell proliferation whereas ERK1 antagonizes ERK2 activity.
	29. 23503 Accesses	Research article Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling Keiji Itoh, Barbara K Brott, Gyu-Un Bae, Marianne J Ratcliffe, Sergei Y Sokol Journal of Biology 2005, 4:3 (15 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, doesn't only function in the cytoplasm and at the cell membrane, but must be imported into the nucleus to perform at least one key aspect of its function.
	30. 21013 Accesses	Opinion Top dogs: wolf domestication and wealth Carlos A Driscoll, David W Macdonald Journal of Biology 2010, 9:10 (24 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on a phylogeographic analysis in BMC Biology that supports a Middle Eastern origin of small dogs, Driscoll and Macdonald speculate on the implications of wolf domestication and size reduction occurring at a time of transition between hunter-gatherer and sedentary societies.
	31. 20976 Accesses	Research article Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach, Sylvia Krobitsch Journal of Biology 2007, 6:10 (21 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Yeast and C. elegans share a conserved cellular mechanism that counteracts the fatal consequences of oxidative stress by enabling the redirection of metabolic flux from glycolysis to the pentose phosphate pathway.
	32. 20687 Accesses	Research article Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone, Frederick P Roth Journal of Biology 2005, 4:6 (1 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The multiple complex biological interactions in a yeast cell can be mapped in a simple graphical form, enhancing our understanding of the networks of interaction by which components of a cell influence one another.
	33. 20282 Accesses	Research article Dosage compensation is less effective in birds than in mammals Yuichiro Itoh, Esther Melamed, Xia Yang, Kathy Kampf, Susanna Wang, Nadir Yehya, Atila Van Nas, Kirstin Replogle, Mark R Band, David F Clayton, Eric E Schadt, Aldons J Lusis, Arthur P Arnold Journal of Biology 2007, 6:2 (22 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Male:female ratios of gene expression in zebra finch and chicken reveal that birds, unlike mammals, have surprisingly ineffective sex-chromosome dosage compensation mechanisms resulting in an imbalance between autosomal and sex-linked genes.
	34. 19678 Accesses	Research article Conservation of core gene expression in vertebrate tissues Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.
	35. 19603 Accesses	Opinion The 'stem cell' concept: is it holding us back? Arthur D Lander Journal of Biology 2009, 8:70 (21 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary Arthur Lander argues that the molecular definition of a stem cell is a mirage and 'stemness' is an emergent property of cells in their physiological context, so that the current concept is arguably an obstacle to research.
	36. 19434 Accesses	Research news Transcriptional territories in the genome Jonathan B Weitzman Journal of Biology 2002, 1:2 (25 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	37. 19397 Accesses	Research article Global analysis of X-chromosome dosage compensation Vaijayanti Gupta, Michael Parisi, David Sturgill, Rachel Nuttall, Michael Doctolero, Olga K Dudko, James D Malley, P Scott Eastman, Brian Oliver Journal of Biology 2006, 5:3 (16 February 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila germ cells, X chromosome genes are upregulated to balance their expression with that of autosomes; the same happens in somatic cells of mice and nematodes.
	38. 18256 Accesses	Editorial What are journals for? Miranda Robertson Journal of Biology 2009, 8:1 (27 January 2009) Full text \| PDF \| Editor’s summary Journal of Biology launches a re-review opt-out experiment in response to widespread dissatisfaction with peer review, and publishes the first of two new regular features - a full review on the ribosome and a question-and-answer feature on systems biology.
	39. 18029 Accesses	Research article A global analysis of genetic interactions in Caenorhabditis elegans Alexandra B Byrne, Matthew T Weirauch, Victoria Wong, Martina Koeva, Scott J Dixon, Joshua M Stuart, Peter J Roy Journal of Biology 2007, 6:8 (26 September 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A C. elegans genetic-interaction network built by combining gene mutants and knockdowns is the largest animal network to date, revealing redundancy among functional modules and surprisingly little conservation of network connections compared to yeast.
	40. 17733 Accesses	Opinion The nature of cell-cycle checkpoints: facts and fallacies Alexey Khodjakov, Conly L Rieder Journal of Biology 2009, 8:88 (16 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The development of the checkpoint concept was a landmark in the understanding of cell cycle control, but Alexey Khodjakov and Conly Rieder argue that it is widely misunderstood, to the detriment of progress in cell cycle research.
	41. 17302 Accesses	Research article Search for a 'Tree of Life' in the thicket of the phylogenetic forest Pere Puigbò, Yuri I Wolf, Eugene V Koonin Journal of Biology 2009, 8:59 (13 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Koonin and colleagues, comparing a forest of 7000 phylogenetic trees, discern vertical inheritance even at the earliest stages of prokaryotic evolution, despite horizontal gene transfer, but the branching order of the earliest radiations may never be resolved.
	42. 17221 Accesses	Opinion Why didn't Darwin discover Mendel's laws? Jonathan C Howard Journal of Biology 2009, 8:15 (24 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In an opinion piece, Jonathan Howard suggests that Darwin failed to discover the laws of inheritance (Mendel’s laws) due to his focus on small quantitative variations as the raw material of evolution.
	43. 16627 Accesses	Research news Stress, sex and evolution Pete Moore Journal of Biology 2003, 2:10 (27 June 2003) Abstract \| Full text \| PDF \| PubMed
	44. 16507 Accesses	Research article Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production Margaret Q Wang, Wankee Kim, Guangxia Gao, Ted A Torrey, Herbert C Morse, Pietro De Camilli, Stephen P Goff Journal of Biology 2003, 3:4 (4 December 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	45. 16449 Accesses	Research article Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function Owain R Millington, Caterina Di Lorenzo, R Phillips, Paul Garside, James M Brewer Journal of Biology 2006, 5:5 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hemozoin pigment, released during malarial infection, is now known to cause dendritic cell failure and subsequent host immunosupression, explaining why people with malaria become prone to infection and respond poorly to vaccines.
	46. 16161 Accesses	Research article Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury Jeannette E Davies, Christoph Pröschel, Ningzhe Zhang, Mark Noble, Margot Mayer-Pröschel, Stephen JA Davies Journal of Biology 2008, 7:24 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Glial cells can promote the repair of damaged spinal cord, but experiments in rats show that while some promote functional recovery others cause abnormal growth and pain, depending on the growth factor used to cultivate them in culture.
	47. 16079 Accesses	Research article The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.
	48. 15634 Accesses	Minireview The mathematics of sexual attraction José A Feijó Journal of Biology 2010, 9:18 (29 March 2010) Abstract \| Full text \| PDF \| PubMed
	49. 15502 Accesses	Minireview Controlling cell division in yeast and animals: does size matter? Savraj S Grewal, Bruce A Edgar Journal of Biology 2003, 2:5 (24 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	50. 15082 Accesses	Research article Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs Andrey V Zavialov, Vasili V Hauryliuk, Måns Ehrenberg Journal of Biology 2005, 4:9 (27 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	51. 15037 Accesses	Review Apes, lice and prehistory Robin A Weiss Journal of Biology 2009, 8:20 (10 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary In a special issue to celebrate the bicentennial of Darwin's birth, Robin Weiss reviews recent speculations on human prehistory based on louse phylogeny, and adds his own on the origins of pubic hair.
	52. 14816 Accesses	Research article A quantitative analysis of the mechanism that controls body size in Manduca sexta HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.
	53. 14523 Accesses	Question & Answer Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus? Stephen J Turner, Lorena E Brown, Peter C Doherty, Anne Kelso Journal of Biology 2009, 8:69 (18 September 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stephen Turner and colleagues follow up their earlier Q&A on influenza A (H1N1) 2009 and ask what we now know about its transmissibility, pathogenicity and variability, and the likelihood of more severe disease in the Northern hemisphere winter.
	54. 14043 Accesses	Research news RNAi and the shape of things to come Jonathan B Weitzman Journal of Biology 2003, 2:23 (4 November 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	55. 13779 Accesses	Research article Electrical protein detection in cell lysates using high-density peptide-aptamer microarrays David Evans, Steven Johnson, Sophie Laurenson, A Giles Davies, Paul Ko Ferrigno, Christoph Wälti Journal of Biology 2008, 7:3 (31 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Specific detection of protein isoforms in whole cell lysates is now more efficient with the arrival of a label-free electronic sensing system consisting of immobilized peptide aptamers on individual gold electrodes at the micron scale.
	56. 13392 Accesses	Minireview Environmental stress and the effects of mutation Santiago F Elena, J Arjan GM de Visser Journal of Biology 2003, 2:12 (26 June 2003) Abstract \| Full text \| PDF \| PubMed
	57. 13305 Accesses	Minireview Parasite immunomodulation and polymorphisms of the immune system Rick M Maizels Journal of Biology 2009, 8:62 (5 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rick Maizels discusses a recent paper in BMC Biology on wild mammals that lend support to the hygiene hypothesis, and explains why genetic variants that reduce parasite-induced immunosuppression are associated with an increase in allergic reactions.
	58. 13275 Accesses	Editorial Journal of Biology celebrates its fifth anniversary Journal of Biology 2007, 6:5 (29 June 2007) Full text \| PDF \| PubMed \| Cited on BioMed Central
	59. 13242 Accesses	Minireview Dishevelled and Wnt signaling: is the nucleus the final frontier? Raymond Habas, Igor B Dawid Journal of Biology 2005, 4:2 (17 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	60. 13233 Accesses	Minireview Infectious causes of cancer and their detection Lucy Dalton-Griffin, Paul Kellam Journal of Biology 2009, 8:67 (11 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Lucy Dalton-Griffin and Paul Kellam discuss the role of viruses in cancer following a recent paper in BMC Medical Genomics describing a new method of detecting viral DNA in cancer cells.
	61. 13168 Accesses	Research news Connecting LKB1 and AMPK links metabolism with cancer Pete Moore Journal of Biology 2003, 2:24 (29 October 2003) Abstract \| Full text \| PDF \| PubMed
	62. 12206 Accesses	Research article A circuit supporting concentration-invariant odor perception in Drosophila Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall Journal of Biology 2009, 8:9 (26 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila, inhibitory interneurons are progressively recruited as olfactory sensory neurons are activated at increasing odor concentrations, allowing the flies to identify distinct odors at different intensities.
	63. 11918 Accesses	Minireview Timing the first human migration into eastern Asia Roscoe Stanyon, Marco Sazzini, Donata Luiselli Journal of Biology 2009, 8:18 (6 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments
	64. 11853 Accesses	Minireview The origin and evolution of lactation Anthony V Capuco, R Michael Akers Journal of Biology 2009, 8:37 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Capuco and Akers review the biology of lactation and discuss a new report in Genome Biology that compares the bovine genome with six other mammalian genomes to study how lactation and its regulation evolved.
	65. 11775 Accesses	Question & Answer Q&A: Epistasis Frederick P Roth, Howard D Lipshitz, Brenda J Andrews Journal of Biology 2009, 8:35 (22 May 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The term epistasis has at least three meanings in biology. Brenda Andrews and colleagues explain in Q&A format how in its classical sense, epistasis allows biological pathways to be defined.
	66. 11697 Accesses	Opinion Promoter architecture and the evolvability of gene expression Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.
	67. 11508 Accesses	Research news Agonizing Hedgehog Jonathan B Weitzman Journal of Biology 2002, 1:7 (6 November 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	68. 11397 Accesses	Minireview The long term effects of chemotherapy on the central nervous system Patricia K Duffner Journal of Biology 2006, 5:21 (30 November 2006) Abstract \| Full text \| PDF \| PubMed
	69. 11297 Accesses	Minireview How chemotherapy damages the central nervous system Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	70. 11125 Accesses	Research article Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.
	71. 11071 Accesses	Minireview Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'? Maria Grazia Lampugnani Journal of Biology 2010, 9:16 (8 April 2010) Abstract \| Full text \| PDF \| PubMed
	72. 11067 Accesses	Minireview The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway Barbara Stecca, Ariel Altaba Journal of Biology 2002, 1:9 (6 November 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	73. 10947 Accesses	Minireview Intestine in the lung Jonathan MW Slack Journal of Biology 2004, 3:10 (8 June 2004) Abstract \| Full text \| PDF \| PubMed
	74. 10768 Accesses	Minireview Combined single-molecule force and fluorescence measurements for biology Mark I Wallace, Justin E Molloy, David R Trentham Journal of Biology 2003, 2:4 (14 April 2003) Abstract \| Full text \| PDF \| PubMed
	75. 10621 Accesses	Research news Controlling how many cells make a fly Pete Moore Journal of Biology 2003, 2:16 (21 August 2003) Abstract \| Full text \| PDF \| PubMed
	76. 10604 Accesses	Minireview Small changes, big results: evolution of morphological discontinuity in mammals Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008) Abstract \| Full text \| PDF \| PubMed
	77. 10565 Accesses	Minireview X-chromosome inactivation: the molecular basis of silencing Barbara Panning Journal of Biology 2008, 7:30 (27 October 2008) Abstract \| Full text \| PDF \| PubMed
	78. 10565 Accesses	Research article Bridge helix and trigger loop perturbations generate superactive RNA polymerases Lin Tan, Simone Wiesler, Dominika Trzaska, Hannah C Carney, Robert OJ Weinzierl Journal of Biology 2008, 7:40 (2 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mutations targeted to key functional areas of RNA polymerases can generate superactive enzymes that suggest how conformational changes in specialized domains of the enzyme contribute to the catalytic cycle.
	79. 10563 Accesses	Question & Answer Q&A: What do we know about influenza and what can we do about it? Peter C Doherty, Stephen J Turner Journal of Biology 2009, 8:46 (26 May 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Peter Doherty and Stephen Turner explain in Q&A format what we know of what determines the pathogenicity and transmissibility of influenza viruses, and the prospects for effective protection.
	80. 10561 Accesses	Minireview Cryptic biodiversity in a changing world Luciano B Beheregaray, Adalgisa Caccone Journal of Biology 2007, 6:9 (21 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	81. 10463 Accesses	Research news Tracking evolution's footprints in the genome Jonathan B Weitzman Journal of Biology 2003, 2:9 (23 June 2003) Abstract \| Full text \| PDF \| PubMed
	82. 10454 Accesses	Minireview The complex genetic basis of simple behavior Anna J Jasinska, Nelson B Freimer Journal of Biology 2009, 8:71 (27 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Jasinska and Freimer discuss a recent paper in BMC Biology by Mackay and colleagues that reveals the complex genetics behind fruitfly aggression, with implications for the dissection of human behaviours
	83. 10411 Accesses	Minireview Functional genomics of cell morphology using RNA interference: pick your style, broad or deep Thomas D Pollard Journal of Biology 2003, 2:25 (1 October 2003) Abstract \| Full text \| PDF \| PubMed
	84. 10402 Accesses	Research news A marriage of techniques Jonathan B Weitzman Journal of Biology 2003, 2:2 (13 March 2003) Abstract \| Full text \| PDF \| PubMed
	85. 10083 Accesses	Minireview The human spermatozoon – a stripped down but refined machine Christopher LR Barratt, Vanessa Kay, Senga K Oxenham Journal of Biology 2009, 8:63 (7 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Christopher Barratt and colleagues review our current knowledge of the human sperm cell and available treatments for male subfertility in the light of a recent paper in BMC Developmental Biology on the role of the annulus.
	86. 9850 Accesses	Minireview Targeting TNF-α for cancer therapy Elizabeth R Burton, Steven K Libutti Journal of Biology 2009, 8:85 (23 October 2009) Abstract \| Full text \| PDF \| PubMed
	87. 9786 Accesses	Minireview At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation John M Kyriakis Journal of Biology 2003, 2:26 (22 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	88. 9785 Accesses	Minireview The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.
	89. 9758 Accesses	Research article Generalized immune activation as a direct result of activated CD4⁺T cell killing Rute Marques, Adam Williams, Urszula Eksmond, Andy Wullaert, Nigel Killeen, Manolis Pasparakis, Dimitris Kioussis, George Kassiotis Journal of Biology 2009, 8:93 (27 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary HIV causes immunodeficiency by deleting activated CD4 T lymphocytes, but paradoxically also causes general immune activation. Kassiotis and colleagues have mimicked this effect by using genetic engineering to delete activated T cells in mice, and show that in the mice it is due to loss of regulatory T cells.
	90. 9536 Accesses	Minireview Regeneration review reprise Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.
	91. 9532 Accesses	Minireview Complementary pathways in mammalian female sex determination Serge Nef, Jean-Dominique Vassalli Journal of Biology 2009, 8:74 (2 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Nef and Vassalli discuss the molecular basis of female sex determination in the light of a recent BMC Developmental Biology paper identifying two independent and complementary signaling pathways that promote ovarian fate and repress testicular development.
	92. 9521 Accesses	Editorial Editorial Martin Raff, Theodora Bloom, Peter Newmark Journal of Biology 2002, 1:1 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	93. 9519 Accesses	Minireview The cattle genome reveals its secrets David W Burt Journal of Biology 2009, 8:36 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.
	94. 9506 Accesses	Minireview Roughing up Smoothened: chemical modulators of Hedgehog signaling Randall W King Journal of Biology 2002, 1:8 (6 November 2002) Abstract \| Full text \| PDF \| PubMed
	95. 9487 Accesses	Minireview Reprogramming of the non-coding transcriptome during brain development Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.
	96. 9473 Accesses	Question & Answer Q&A: Systems biology James E Ferrell Journal of Biology 2009, 8:2 (26 January 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central
	97. 9314 Accesses	Research news Making sense of centromeres Pete Moore Journal of Biology 2004, 3:16 (31 August 2004) Abstract \| Full text \| PDF \| PubMed
	98. 9284 Accesses	Research news Growing without a size checkpoint Jonathan B Weitzman Journal of Biology 2003, 2:3 (24 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	99. 9273 Accesses	Question & Answer Q&A: What are pharmacological chaperones and why are they interesting? Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009) Full text \| PDF \| PubMed \| Editor’s summary Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
	100. 9204 Accesses	Minireview Limb regeneration revisited Jessica L Whited, Clifford J Tabin Journal of Biology 2009, 8:5 (13 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central