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26.

26395
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Gene expression neighborhoods

Brian Oliver, Michael Parisi, David Clark Journal of Biology 2002, 1:4 (1 July 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

25635
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Music, memory and emotion

Lutz Jäncke Journal of Biology 2008, 7:21 (8 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

25016
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ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially

Chiara Vantaggiato, Ivan Formentini, Attilio Bondanza, Chiara Bonini, Luigi Naldini, Riccardo Brambilla Journal of Biology 2006, 5:14 (28 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The mitogen-activated protein kinases ERK1 and ERK2 have unexpectedly independent roles in normal and malignant Ras-dependent cell proliferation; ERK2 controls normal cell proliferation whereas ERK1 antagonizes ERK2 activity.

29.

23534
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Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

Keiji Itoh, Barbara K Brott, Gyu-Un Bae, Marianne J Ratcliffe, Sergei Y Sokol Journal of Biology 2005, 4:3 (15 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, doesn't only function in the cytoplasm and at the cell membrane, but must be imported into the nucleus to perform at least one key aspect of its function.

30.

21090
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Opinion   Free Highly Accessed

Top dogs: wolf domestication and wealth

Carlos A Driscoll, David W Macdonald Journal of Biology 2010, 9:10 (24 February 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Commenting on a phylogeographic analysis in BMC Biology that supports a Middle Eastern origin of small dogs, Driscoll and Macdonald speculate on the implications of wolf domestication and size reduction occurring at a time of transition between hunter-gatherer and sedentary societies.

31.

21047
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Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach, Sylvia Krobitsch Journal of Biology 2007, 6:10 (21 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Yeast and C. elegans share a conserved cellular mechanism that counteracts the fatal consequences of oxidative stress by enabling the redirection of metabolic flux from glycolysis to the pentose phosphate pathway.

32.

20726
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Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network

Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone, Frederick P Roth Journal of Biology 2005, 4:6 (1 June 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The multiple complex biological interactions in a yeast cell can be mapped in a simple graphical form, enhancing our understanding of the networks of interaction by which components of a cell influence one another.

33.

20317
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Dosage compensation is less effective in birds than in mammals

Yuichiro Itoh, Esther Melamed, Xia Yang, Kathy Kampf, Susanna Wang, Nadir Yehya, Atila Van Nas, Kirstin Replogle, Mark R Band, David F Clayton, Eric E Schadt, Aldons J Lusis, Arthur P Arnold Journal of Biology 2007, 6:2 (22 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Male:female ratios of gene expression in zebra finch and chicken reveal that birds, unlike mammals, have surprisingly ineffective sex-chromosome dosage compensation mechanisms resulting in an imbalance between autosomal and sex-linked genes.

34.

19724
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Conservation of core gene expression in vertebrate tissues

Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael JH Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes Journal of Biology 2009, 8:33 (16 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

High conservation of tissue-specific expression is found across vertebrates yet there is a lack of conservation in common regulatory sequences/signatures.

35.

19637
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The 'stem cell' concept: is it holding us back?

Arthur D Lander Journal of Biology 2009, 8:70 (21 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

Arthur Lander argues that the molecular definition of a stem cell is a mirage and 'stemness' is an emergent property of cells in their physiological context, so that the current concept is arguably an obstacle to research.

36.

19452
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Research news   Free

Transcriptional territories in the genome

Jonathan B Weitzman Journal of Biology 2002, 1:2 (25 June 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

19436
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Global analysis of X-chromosome dosage compensation

Vaijayanti Gupta, Michael Parisi, David Sturgill, Rachel Nuttall, Michael Doctolero, Olga K Dudko, James D Malley, P Scott Eastman, Brian Oliver Journal of Biology 2006, 5:3 (16 February 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

In Drosophila germ cells, X chromosome genes are upregulated to balance their expression with that of autosomes; the same happens in somatic cells of mice and nematodes.

38.

18308
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What are journals for?

Miranda Robertson Journal of Biology 2009, 8:1 (27 January 2009)

Full text | PDF |  Editor’s summary

Journal of Biology launches a re-review opt-out experiment in response to widespread dissatisfaction with peer review, and publishes the first of two new regular features - a full review on the ribosome and a question-and-answer feature on systems biology.

39.

18074
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A global analysis of genetic interactions in Caenorhabditis elegans

Alexandra B Byrne, Matthew T Weirauch, Victoria Wong, Martina Koeva, Scott J Dixon, Joshua M Stuart, Peter J Roy Journal of Biology 2007, 6:8 (26 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A C. elegans genetic-interaction network built by combining gene mutants and knockdowns is the largest animal network to date, revealing redundancy among functional modules and surprisingly little conservation of network connections compared to yeast.

40.

17768
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The nature of cell-cycle checkpoints: facts and fallacies

Alexey Khodjakov, Conly L Rieder Journal of Biology 2009, 8:88 (16 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The development of the checkpoint concept was a landmark in the understanding of cell cycle control, but Alexey Khodjakov and Conly Rieder argue that it is widely misunderstood, to the detriment of progress in cell cycle research.

41.

17344
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Search for a 'Tree of Life' in the thicket of the phylogenetic forest

Pere Puigbò, Yuri I Wolf, Eugene V Koonin Journal of Biology 2009, 8:59 (13 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Koonin and colleagues, comparing a forest of 7000 phylogenetic trees, discern vertical inheritance even at the earliest stages of prokaryotic evolution, despite horizontal gene transfer, but the branching order of the earliest radiations may never be resolved.

42.

17262
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Why didn't Darwin discover Mendel's laws?

Jonathan C Howard Journal of Biology 2009, 8:15 (24 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In an opinion piece, Jonathan Howard suggests that Darwin failed to discover the laws of inheritance (Mendel’s laws) due to his focus on small quantitative variations as the raw material of evolution.

43.

16647
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Stress, sex and evolution

Pete Moore Journal of Biology 2003, 2:10 (27 June 2003)

Abstract | Full text | PDF | PubMed

44.

16541
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Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production

Margaret Q Wang, Wankee Kim, Guangxia Gao, Ted A Torrey, Herbert C Morse, Pietro De Camilli, Stephen P Goff Journal of Biology 2003, 3:4 (4 December 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

45.

16491
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Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function

Owain R Millington, Caterina Di Lorenzo, R Phillips, Paul Garside, James M Brewer Journal of Biology 2006, 5:5 (12 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Hemozoin pigment, released during malarial infection, is now known to cause dendritic cell failure and subsequent host immunosupression, explaining why people with malaria become prone to infection and respond poorly to vaccines.

46.

16198
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Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury

Jeannette E Davies, Christoph Pröschel, Ningzhe Zhang, Mark Noble, Margot Mayer-Pröschel, Stephen JA Davies Journal of Biology 2008, 7:24 (19 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Glial cells can promote the repair of damaged spinal cord, but experiments in rats show that while some promote functional recovery others cause abnormal growth and pain, depending on the growth factor used to cultivate them in culture.

47.

16139
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The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans

Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.

48.

15704
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The mathematics of sexual attraction

José A Feijó Journal of Biology 2010, 9:18 (29 March 2010)

Abstract | Full text | PDF | PubMed

49.

15522
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Controlling cell division in yeast and animals: does size matter?

Savraj S Grewal, Bruce A Edgar Journal of Biology 2003, 2:5 (24 April 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

15099
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Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs

Andrey V Zavialov, Vasili V Hauryliuk, Måns Ehrenberg Journal of Biology 2005, 4:9 (27 June 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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