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51.

15147
Accesses

Research article   Open Access Highly Accessed

Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs

Andrey V Zavialov, Vasili V Hauryliuk, Måns Ehrenberg Journal of Biology 2005, 4:9 (27 June 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

52.

14937
Accesses

Research article   Open Access Highly Accessed

A quantitative analysis of the mechanism that controls body size in Manduca sexta

HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.

53.

14621
Accesses

Question & Answer   Free Highly Accessed

Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus?

Stephen J Turner, Lorena E Brown, Peter C Doherty, Anne Kelso Journal of Biology 2009, 8:69 (18 September 2009)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Stephen Turner and colleagues follow up their earlier Q&A on influenza A (H1N1) 2009 and ask what we now know about its transmissibility, pathogenicity and variability, and the likelihood of more severe disease in the Northern hemisphere winter.

54.

14102
Accesses

Research news   Free Highly Accessed

RNAi and the shape of things to come

Jonathan B Weitzman Journal of Biology 2003, 2:23 (4 November 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

55.

13910
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Research article   Open Access Highly Accessed

Electrical protein detection in cell lysates using high-density peptide-aptamer microarrays

David Evans, Steven Johnson, Sophie Laurenson, A Giles Davies, Paul Ko Ferrigno, Christoph Wälti Journal of Biology 2008, 7:3 (31 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Specific detection of protein isoforms in whole cell lysates is now more efficient with the arrival of a label-free electronic sensing system consisting of immobilized peptide aptamers on individual gold electrodes at the micron scale.

56.

13527
Accesses

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Environmental stress and the effects of mutation

Santiago F Elena, J Arjan GM de Visser Journal of Biology 2003, 2:12 (26 June 2003)

Abstract | Full text | PDF | PubMed

57.

13519
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Parasite immunomodulation and polymorphisms of the immune system

Rick M Maizels Journal of Biology 2009, 8:62 (5 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Rick Maizels discusses a recent paper in BMC Biology on wild mammals that lend support to the hygiene hypothesis, and explains why genetic variants that reduce parasite-induced immunosuppression are associated with an increase in allergic reactions.

58.

13359
Accesses

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Dishevelled and Wnt signaling: is the nucleus the final frontier?

Raymond Habas, Igor B Dawid Journal of Biology 2005, 4:2 (17 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

59.

13355
Accesses

Editorial   Open Access Highly Accessed

Journal of Biology celebrates its fifth anniversary

Journal of Biology 2007, 6:5 (29 June 2007)

Full text | PDF | PubMed | Cited on BioMed Central

60.

13342
Accesses

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Infectious causes of cancer and their detection

Lucy Dalton-Griffin, Paul Kellam Journal of Biology 2009, 8:67 (11 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Lucy Dalton-Griffin and Paul Kellam discuss the role of viruses in cancer following a recent paper in BMC Medical Genomics describing a new method of detecting viral DNA in cancer cells.

61.

13249
Accesses

Research news   Free

Connecting LKB1 and AMPK links metabolism with cancer

Pete Moore Journal of Biology 2003, 2:24 (29 October 2003)

Abstract | Full text | PDF | PubMed

62.

12408
Accesses

Research article   Open Access Highly Accessed

A circuit supporting concentration-invariant odor perception in Drosophila

Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall Journal of Biology 2009, 8:9 (26 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

In Drosophila, inhibitory interneurons are progressively recruited as olfactory sensory neurons are activated at increasing odor concentrations, allowing the flies to identify distinct odors at different intensities.

63.

12142
Accesses

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The origin and evolution of lactation

Anthony V Capuco, R Michael Akers Journal of Biology 2009, 8:37 (24 April 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Capuco and Akers review the biology of lactation and discuss a new report in Genome Biology that compares the bovine genome with six other mammalian genomes to study how lactation and its regulation evolved.

64.

12113
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Timing the first human migration into eastern Asia

Roscoe Stanyon, Marco Sazzini, Donata Luiselli Journal of Biology 2009, 8:18 (6 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

65.

11977
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Question & Answer   Free Highly Accessed

Q&A: Epistasis

Frederick P Roth, Howard D Lipshitz, Brenda J Andrews Journal of Biology 2009, 8:35 (22 May 2009)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The term epistasis has at least three meanings in biology. Brenda Andrews and colleagues explain in Q&A format how in its classical sense, epistasis allows biological pathways to be defined.

66.

11851
Accesses

Opinion   Free Highly Accessed

Promoter architecture and the evolvability of gene expression

Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.

67.

11564
Accesses

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Agonizing Hedgehog

Jonathan B Weitzman Journal of Biology 2002, 1:7 (6 November 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

68.

11510
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The long term effects of chemotherapy on the central nervous system

Patricia K Duffner Journal of Biology 2006, 5:21 (30 November 2006)

Abstract | Full text | PDF | PubMed

69.

11427
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How chemotherapy damages the central nervous system

Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

70.

11333
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Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'?

Maria Grazia Lampugnani Journal of Biology 2010, 9:16 (8 April 2010)

Abstract | Full text | PDF | PubMed

71.

11301
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Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.

72.

11138
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Small changes, big results: evolution of morphological discontinuity in mammals

Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008)

Abstract | Full text | PDF | PubMed

73.

11121
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The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway

Barbara Stecca, Ariel Altaba Journal of Biology 2002, 1:9 (6 November 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

74.

11029
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Intestine in the lung

Jonathan MW Slack Journal of Biology 2004, 3:10 (8 June 2004)

Abstract | Full text | PDF | PubMed

75.

10837
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Combined single-molecule force and fluorescence measurements for biology

Mark I Wallace, Justin E Molloy, David R Trentham Journal of Biology 2003, 2:4 (14 April 2003)

Abstract | Full text | PDF | PubMed

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