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76.
10604 Accesses
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Small changes, big results: evolution of morphological discontinuity in mammals
Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008)
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77.
10565 Accesses
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X-chromosome inactivation: the molecular basis of silencing
Barbara Panning Journal of Biology 2008, 7:30 (27 October 2008)
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78.
10565 Accesses
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Bridge helix and trigger loop perturbations generate superactive RNA polymerases
Lin Tan, Simone Wiesler, Dominika Trzaska, Hannah C Carney, Robert OJ Weinzierl Journal of Biology 2008, 7:40 (2 December 2008)
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Editor’s summary
Mutations targeted to key functional areas of RNA polymerases can generate superactive enzymes that suggest how conformational changes in specialized domains of the enzyme contribute to the catalytic cycle.
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79.
10563 Accesses
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Q&A: What do we know about influenza and what can we do about it?
Peter C Doherty, Stephen J Turner Journal of Biology 2009, 8:46 (26 May 2009)
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Editor’s summary
Peter Doherty and Stephen Turner explain in Q&A format what we know of what determines the pathogenicity and transmissibility of influenza viruses, and the prospects for effective protection.
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80.
10561 Accesses
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Cryptic biodiversity in a changing world
Luciano B Beheregaray, Adalgisa Caccone Journal of Biology 2007, 6:9 (21 December 2007)
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81.
10463 Accesses
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Tracking evolution's footprints in the genome
Jonathan B Weitzman Journal of Biology 2003, 2:9 (23 June 2003)
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82.
10454 Accesses
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The complex genetic basis of simple behavior
Anna J Jasinska, Nelson B Freimer Journal of Biology 2009, 8:71 (27 August 2009)
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Editor’s summary
Jasinska and Freimer discuss a recent paper in BMC Biology by Mackay and colleagues that reveals the complex genetics behind fruitfly aggression, with implications for the dissection of human behaviours
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83.
10411 Accesses
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Functional genomics of cell morphology using RNA interference: pick your style, broad or deep
Thomas D Pollard Journal of Biology 2003, 2:25 (1 October 2003)
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84.
10402 Accesses
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A marriage of techniques
Jonathan B Weitzman Journal of Biology 2003, 2:2 (13 March 2003)
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85.
10083 Accesses
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The human spermatozoon – a stripped down but refined machine
Christopher LR Barratt, Vanessa Kay, Senga K Oxenham Journal of Biology 2009, 8:63 (7 August 2009)
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Editor’s summary
Christopher Barratt and colleagues review our current knowledge of the human sperm cell and available treatments for male subfertility in the light of a recent paper in BMC Developmental Biology on the role of the annulus.
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86.
9850 Accesses
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Targeting TNF-α for cancer therapy
Elizabeth R Burton, Steven K Libutti Journal of Biology 2009, 8:85 (23 October 2009)
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87.
9786 Accesses
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At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation
John M Kyriakis Journal of Biology 2003, 2:26 (22 October 2003)
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88.
9785 Accesses
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The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics
Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009)
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Editor’s summary
Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.
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89.
9758 Accesses
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Generalized immune activation as a direct result of activated CD4+ T cell killing
Rute Marques, Adam Williams, Urszula Eksmond, Andy Wullaert, Nigel Killeen, Manolis Pasparakis, Dimitris Kioussis, George Kassiotis Journal of Biology 2009, 8:93 (27 November 2009)
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Editor’s summary
HIV causes immunodeficiency by deleting activated CD4 T lymphocytes, but paradoxically also causes general immune activation. Kassiotis and colleagues have mimicked this effect by using genetic engineering to delete activated T cells in mice, and show that in the mice it is due to loss of regulatory T cells.
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90.
9536 Accesses
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Regeneration review reprise
Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010)
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Editor’s summary
Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.
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91.
9532 Accesses
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Complementary pathways in mammalian female sex determination
Serge Nef, Jean-Dominique Vassalli Journal of Biology 2009, 8:74 (2 September 2009)
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Editor’s summary
Nef and Vassalli discuss the molecular basis of female sex determination in the light of a recent BMC Developmental Biology paper identifying two independent and complementary signaling pathways that promote ovarian fate and repress testicular development.
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92.
9521 Accesses
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Editorial
Martin Raff, Theodora Bloom, Peter Newmark Journal of Biology 2002, 1:1 (18 June 2002)
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93.
9519 Accesses
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The cattle genome reveals its secrets
David W Burt Journal of Biology 2009, 8:36 (24 April 2009)
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Editor’s summary
Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.
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94.
9506 Accesses
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Roughing up Smoothened: chemical modulators of Hedgehog signaling
Randall W King Journal of Biology 2002, 1:8 (6 November 2002)
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95.
9487 Accesses
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Reprogramming of the non-coding transcriptome during brain development
Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010)
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Editor’s summary
Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.
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96.
9473 Accesses
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Q&A: Systems biology
James E Ferrell Journal of Biology 2009, 8:2 (26 January 2009)
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97.
9314 Accesses
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Making sense of centromeres
Pete Moore Journal of Biology 2004, 3:16 (31 August 2004)
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98.
9284 Accesses
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Growing without a size checkpoint
Jonathan B Weitzman Journal of Biology 2003, 2:3 (24 April 2003)
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99.
9273 Accesses
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Q&A: What are pharmacological chaperones and why are they interesting?
Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009)
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Editor’s summary
Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
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100.
9204 Accesses
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Limb regeneration revisited
Jessica L Whited, Clifford J Tabin Journal of Biology 2009, 8:5 (13 January 2009)
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