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76.

10604
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Small changes, big results: evolution of morphological discontinuity in mammals

Rodney L Honeycutt Journal of Biology 2008, 7:9 (18 March 2008)

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77.

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X-chromosome inactivation: the molecular basis of silencing

Barbara Panning Journal of Biology 2008, 7:30 (27 October 2008)

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78.

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Research article   Open Access

Bridge helix and trigger loop perturbations generate superactive RNA polymerases

Lin Tan, Simone Wiesler, Dominika Trzaska, Hannah C Carney, Robert OJ Weinzierl Journal of Biology 2008, 7:40 (2 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Mutations targeted to key functional areas of RNA polymerases can generate superactive enzymes that suggest how conformational changes in specialized domains of the enzyme contribute to the catalytic cycle.

79.

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Q&A: What do we know about influenza and what can we do about it?

Peter C Doherty, Stephen J Turner Journal of Biology 2009, 8:46 (26 May 2009)

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Peter Doherty and Stephen Turner explain in Q&A format what we know of what determines the pathogenicity and transmissibility of influenza viruses, and the prospects for effective protection.

80.

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Cryptic biodiversity in a changing world

Luciano B Beheregaray, Adalgisa Caccone Journal of Biology 2007, 6:9 (21 December 2007)

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81.

10463
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Tracking evolution's footprints in the genome

Jonathan B Weitzman Journal of Biology 2003, 2:9 (23 June 2003)

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82.

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The complex genetic basis of simple behavior

Anna J Jasinska, Nelson B Freimer Journal of Biology 2009, 8:71 (27 August 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Jasinska and Freimer discuss a recent paper in BMC Biology by Mackay and colleagues that reveals the complex genetics behind fruitfly aggression, with implications for the dissection of human behaviours

83.

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Functional genomics of cell morphology using RNA interference: pick your style, broad or deep

Thomas D Pollard Journal of Biology 2003, 2:25 (1 October 2003)

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A marriage of techniques

Jonathan B Weitzman Journal of Biology 2003, 2:2 (13 March 2003)

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85.

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The human spermatozoon – a stripped down but refined machine

Christopher LR Barratt, Vanessa Kay, Senga K Oxenham Journal of Biology 2009, 8:63 (7 August 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Christopher Barratt and colleagues review our current knowledge of the human sperm cell and available treatments for male subfertility in the light of a recent paper in BMC Developmental Biology on the role of the annulus.

86.

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Targeting TNF-α for cancer therapy

Elizabeth R Burton, Steven K Libutti Journal of Biology 2009, 8:85 (23 October 2009)

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At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

John M Kyriakis Journal of Biology 2003, 2:26 (22 October 2003)

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The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics

Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.

89.

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Generalized immune activation as a direct result of activated CD4+ T cell killing

Rute Marques, Adam Williams, Urszula Eksmond, Andy Wullaert, Nigel Killeen, Manolis Pasparakis, Dimitris Kioussis, George Kassiotis Journal of Biology 2009, 8:93 (27 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

HIV causes immunodeficiency by deleting activated CD4 T lymphocytes, but paradoxically also causes general immune activation. Kassiotis and colleagues have mimicked this effect by using genetic engineering to delete activated T cells in mice, and show that in the mice it is due to loss of regulatory T cells.

90.

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Regeneration review reprise

Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.

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Complementary pathways in mammalian female sex determination

Serge Nef, Jean-Dominique Vassalli Journal of Biology 2009, 8:74 (2 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Nef and Vassalli discuss the molecular basis of female sex determination in the light of a recent BMC Developmental Biology paper identifying two independent and complementary signaling pathways that promote ovarian fate and repress testicular development.

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Editorial   Open Access

Editorial

Martin Raff, Theodora Bloom, Peter Newmark Journal of Biology 2002, 1:1 (18 June 2002)

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The cattle genome reveals its secrets

David W Burt Journal of Biology 2009, 8:36 (24 April 2009)

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Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.

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Roughing up Smoothened: chemical modulators of Hedgehog signaling

Randall W King Journal of Biology 2002, 1:8 (6 November 2002)

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Reprogramming of the non-coding transcriptome during brain development

Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.

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Q&A: Systems biology

James E Ferrell Journal of Biology 2009, 8:2 (26 January 2009)

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Making sense of centromeres

Pete Moore Journal of Biology 2004, 3:16 (31 August 2004)

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Growing without a size checkpoint

Jonathan B Weitzman Journal of Biology 2003, 2:3 (24 April 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Q&A: What are pharmacological chaperones and why are they interesting?

Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009)

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Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.

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Limb regeneration revisited

Jessica L Whited, Clifford J Tabin Journal of Biology 2009, 8:5 (13 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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