Journal of Biology - Most accessed articles
http://jbiol.com/
The most accessed research articles published by Journal of Biology2010-03-11T00:00:00Z
This is an RSS newsfeed from BioMed Central
It is intended to be used with an RSS reader. For more information about RSS newsfeeds from BioMed Central, visit
http://www.biomedcentral.com/info/about/rss/
Top dogs: wolf domestication and wealthA phylogeographic analysis of gene sequences important in determining body size in dogs, recently published in BMC Biology, traces the appearance of small body size to the Neolithic Middle East. This finding strengthens the association of this event with the development of sedentary societies, and perhaps even has implications for the inception of human social inequality.See research article http://www.biomedcentral.com/1741-7007/8/16/
http://jbiol.com/content/9/2/10
Journal of Biology 2010, 9:102010-02-24T00:00:00Zdoi:10.1186/jbiol226Journal of Biology1475-49249102010-02-24T00:00:00ZXMLRegeneration review repriseThere have been notable advances in the scientific understanding of regeneration within the past year alone, including two recently published in BMC Biology. Increasingly, progress in the regeneration field is being inspired by comparisons with stem cell biology and enabled by newly developed techniques that allow simultaneous examination of thousands of genes and proteins.See research articles http://www.biomedcentral.com/1741-7007/7/83 and http://www.biomedcentral.com/1741-7007/8/5.
http://jbiol.com/content/9/2/15
Journal of Biology 2010, 9:152010-02-16T00:00:00Zdoi:10.1186/jbiol224Journal of Biology1475-49249152010-02-16T00:00:00ZXMLNo better time to FRET: shedding light on host pathogen interactionsUnderstanding the spatio-temporal subversion of host cell signaling by bacterial virulence factors is key to combating infectious diseases. Following a recent study by Buntru and co-workers published in BMC Biology, we review how fluorescence (Forster) resonance energy transfer (FRET) has been applied to studying host-pathogen interactions and consider the prospects for its future application.See research article http://www.biomedcentral.com/1741-7007/7/81.
http://jbiol.com/content/9/2/12
Journal of Biology 2010, 9:122010-02-18T00:00:00Zdoi:10.1186/jbiol225Journal of Biology1475-49249122010-02-18T00:00:00ZXMLMaking progress in genetic kin recognition among vertebratesA recent study in BMC Evolutionary Biology has shown that genetically similar individual ring-tailed lemurs are also more similar in their scent composition, suggesting a possible mechanism of kin recognition. Theoretical and experimental studies reveal challenges ahead in achieving a true systems-level understanding of this process and its outcomes.See research article http://www.biomedcentral.com/1471-2148/9/281.
http://jbiol.com/content/9/2/13
Journal of Biology 2010, 9:132010-02-17T00:00:00Zdoi:10.1186/jbiol221Journal of Biology1475-49249132010-02-17T00:00:00ZXMLScale-eating cichlids: from hand(ed) to mouthTwo recent studies in BMC Biology and Evolution raise important questions about a textbook case of frequency-dependent selection in scale-eating cichlid fishes. They also suggest a fascinating new line of research testing the effects of handed behavior on morphological asymmetry.See research article http://www.biomedcentral.com/1741-7007/8/8.
http://jbiol.com/content/9/2/11
Journal of Biology 2010, 9:112010-02-24T00:00:00Zdoi:10.1186/jbiol218Journal of Biology1475-49249112010-02-24T00:00:00ZXMLReprogramming of the non-coding transcriptome during brain developmentA recent global analysis of gene expression during the differentiation of neuronal stem cells to neurons and oligodendrocytes indicates a complex pattern of changes in the expression of both protein-coding transcripts and long non-protein-coding RNAs.See research article http://www.biomedcentral.com/1471-2202/11/14.
http://jbiol.com/content/9/1/5
Journal of Biology 2010, 9:52010-02-05T00:00:00Zdoi:10.1186/jbiol197Journal of Biology1475-4924952010-02-05T00:00:00ZXMLEvolution underground: shedding light on the diversification of subterranean insectsA recent study in BMC Evolutionary Biology has reconstructed the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade, revealing an ancient origin and strong geographic structuring. It seems likely that diversification of this clade in the Oligocene was seeded by an ancestor already adapted to subterranean life.See research article http://www.biomedcentral.com/1471-2148/10/29
http://jbiol.com/content/9/3/17
Journal of Biology 2010, 9:172010-03-11T00:00:00Zdoi:10.1186/jbiol227Journal of Biology1475-49249172010-03-11T00:00:00ZXMLAcoel and platyhelminth models for stem-cell researchAcoel and platyhelminth worms are particularly attractive invertebrate models for stem-cell research because their bodies are continually renewed from large pools of somatic stem cells. Several recent studies, including one in BMC Developmental Biology, are beginning to reveal the cellular dynamics and molecular basis of stem-cell function in these animals.See research article http://www.biomedcentral.com/1471-213X/9/69.
http://jbiol.com/content/9/2/14
Journal of Biology 2010, 9:142010-02-16T00:00:00Zdoi:10.1186/jbiol223Journal of Biology1475-49249142010-02-16T00:00:00ZXMLRegulation of metabolism in Caenorhabditis elegans longevityThe nematode Caenorhabditis elegans is a favorite model for the study of aging. A wealth of genetic and genomic studies show that metabolic regulation is a hallmark of life-span modulation. A recent study in BMC Biology identifying metabolic signatures for longevity suggests that amino-acid pools may be important in longevity.See research article http://www.biomedcentral.com/1741-7007/8/14.
http://jbiol.com/content/9/1/7
Journal of Biology 2010, 9:72010-02-10T00:00:00Zdoi:10.1186/jbiol215Journal of Biology1475-4924972010-02-10T00:00:00ZXMLMadm (Mlf1 adapter molecule) co-operates with Bunched A to promote growth in DrosophilaBackground:
The TSC-22 domain family (TSC22DF) consists of putative transcription factors harboring a DNA-binding TSC-box and an adjacent leucine zipper at their carboxyl termini. Both short and long TSC22DF isoforms are conserved from flies to humans. Whereas the short isoforms include the tumor suppressor TSC-22 (Transforming growth factor-β1 stimulated clone-22), the long isoforms are largely uncharacterized. In Drosophila, the long isoform Bunched A (BunA) acts as a growth promoter, but how BunA controls growth has remained obscure.
Results:
In order to test for functional conservation among TSC22DF members, we expressed the human TSC22DF proteins in the fly and found that all long isoforms can replace BunA function. Furthermore, we combined a proteomics-based approach with a genetic screen to identify proteins that interact with BunA. Madm (Mlf1 adapter molecule) physically associates with BunA via a conserved motif that is only contained in long TSC22DF proteins. Moreover, Drosophila Madm acts as a growth-promoting gene that displays growth phenotypes strikingly similar to bunA phenotypes. When overexpressed, Madm and BunA synergize to increase organ growth.
Conclusions:
The growth-promoting potential of long TSC22DF proteins is evolutionarily conserved. Furthermore, we provide biochemical and genetic evidence for a growth-regulating complex involving the long TSC22DF protein BunA and the adapter molecule Madm.See minireview at http://jbiol.com/content/9/1/8.
http://jbiol.com/content/9/1/9
Silvia GludererErich BrunnerMarkus GermannVirginija JovaisaiteChangqing LiCyrill RentschErnst HafenHugo StockerJournal of Biology 2010, 9:92010-02-11T00:00:00Zdoi:10.1186/jbiol216Journal of Biology1475-4924992010-02-11T00:00:00ZXML