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	51. 2218 Accesses	Minireview Regulation of metabolism in Caenorhabditis elegans longevity Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.
	52. 2210 Accesses	Research article A global analysis of genetic interactions in Caenorhabditis elegans Alexandra B Byrne, Matthew T Weirauch, Victoria Wong, Martina Koeva, Scott J Dixon, Joshua M Stuart, Peter J Roy Journal of Biology 2007, 6:8 (26 September 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A C. elegans genetic-interaction network built by combining gene mutants and knockdowns is the largest animal network to date, revealing redundancy among functional modules and surprisingly little conservation of network connections compared to yeast.
	53. 2202 Accesses	Research article Astrocytes derived from glial-restricted precursors promote spinal cord repair Jeannette E Davies, Carol Huang, Christoph Proschel, Mark Noble, Margot Mayer-Proschel, Stephen JA Davies Journal of Biology 2006, 5:7 (27 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Significantly better spinal cord repair in rats results from transplanting specific pre-differentiated cells, cultured to become immature neural-support cells, than from transplanting undifferentiated embryonic stem cells.
	54. 2130 Accesses	Minireview How chemotherapy damages the central nervous system Christina A Meyers Journal of Biology 2008, 7:11 (22 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	55. 2089 Accesses	Research article A circuit supporting concentration-invariant odor perception in Drosophila Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall Journal of Biology 2009, 8:9 (26 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila, inhibitory interneurons are progressively recruited as olfactory sensory neurons are activated at increasing odor concentrations, allowing the flies to identify distinct odors at different intensities.
	56. 2085 Accesses	Research article The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz, Michael O Hengartner Journal of Biology 2006, 5:9 (25 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Newly characterized in C. elegans, the protein UNC-69 interacts with kinesin–binding protein UNC-76 in a complex associated with trafficking vesicles along axons - a process that drives axon growth and helps synapse formation.
	57. 2079 Accesses	Minireview Metabolic reconfiguration is a regulated response to oxidative stress Chris M Grant Journal of Biology 2008, 7:1 (25 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	58. 2043 Accesses	Research article Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone, Frederick P Roth Journal of Biology 2005, 4:6 (1 June 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The multiple complex biological interactions in a yeast cell can be mapped in a simple graphical form, enhancing our understanding of the networks of interaction by which components of a cell influence one another.
	59. 2037 Accesses	Opinion Promoter architecture and the evolvability of gene expression Itay Tirosh, Naama Barkai, Kevin J Verstrepen Journal of Biology 2009, 8:95 (14 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Major evolutionary change depends on changes in gene expression. Itay Tirosh and colleagues review recent research on the influence of promoter architecture and mutations in regulatory proteins on divergent expression patterns and suggest what is required for evolvability.
	60. 2010 Accesses	Opinion The 'stem cell' concept: is it holding us back? Arthur D Lander Journal of Biology 2009, 8:70 (21 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 2 comments \| Editor’s summary Arthur Lander argues that the molecular definition of a stem cell is a mirage and 'stemness' is an emergent property of cells in their physiological context, so that the current concept is arguably an obstacle to research.
	61. 1980 Accesses	Minireview The cattle genome reveals its secrets David W Burt Journal of Biology 2009, 8:36 (24 April 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Burt discusses the impact of the recently sequenced Bovine genome on our understanding of bovine phylogeny and the genomics of domestication.
	62. 1972 Accesses	Research article Evidence for large domains of similarly expressed genes in the Drosophila genome Paul T Spellman, Gerald M Rubin Journal of Biology 2002, 1:5 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	63. 1971 Accesses	Research article Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance Basil Honegger, Milos Galic, Katja Köhler, Franz Wittwer, Walter Brogiolo, Ernst Hafen, Hugo Stocker Journal of Biology 2008, 7:10 (15 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first functional insulin-binding protein identified in invertebrates, Imp-L2, controls Drosophila body size by regulating insulin-mediated growth and is essential for larval survival and dampening insulin signaling under starvation conditions.
	64. 1962 Accesses	Research article Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression Ian Conlon, Martin Raff Journal of Biology 2003, 2:7 (24 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 4 comments \| F1000 Biology
	65. 1955 Accesses	Minireview Regeneration review reprise Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.
	66. 1947 Accesses	Research article Global analysis of X-chromosome dosage compensation Vaijayanti Gupta, Michael Parisi, David Sturgill, Rachel Nuttall, Michael Doctolero, Olga K Dudko, James D Malley, P Scott Eastman, Brian Oliver Journal of Biology 2006, 5:3 (16 February 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In Drosophila germ cells, X chromosome genes are upregulated to balance their expression with that of autosomes; the same happens in somatic cells of mice and nematodes.
	67. 1946 Accesses	Question & Answer Q&A: What are pharmacological chaperones and why are they interesting? Dagmar Ringe, Gregory A Petsko Journal of Biology 2009, 8:80 (13 October 2009) Full text \| PDF \| PubMed \| Editor’s summary Small molecules that stabilize mutant proteins with high specificity can be used to treat protein misfolding and metabolic diseases: in a Q&A highlighting recent successes, Dagmar Ringe and Gregory Petsko explain how.
	68. 1924 Accesses	Research article Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury Jeannette E Davies, Christoph Pröschel, Ningzhe Zhang, Mark Noble, Margot Mayer-Pröschel, Stephen JA Davies Journal of Biology 2008, 7:24 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Glial cells can promote the repair of damaged spinal cord, but experiments in rats show that while some promote functional recovery others cause abnormal growth and pain, depending on the growth factor used to cultivate them in culture.
	69. 1900 Accesses	Minireview The genetics of gender and life span John Tower, Michelle Arbeitman Journal of Biology 2009, 8:38 (29 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Tower and Arbeitman discuss two studies in BMC Evolutionary Biology showing that the genetic differences between male and female seed beetles and in fruit flies have a significant effect upon aging and life span.
	70. 1895 Accesses	Review Notch signaling, the segmentation clock, and the patterning of vertebrate somites Julian Lewis, Anja Hanisch, Maxine Holder Journal of Biology 2009, 8:44 (22 May 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Julian Lewis and colleagues review the part played by the Notch signaling pathway in the emergence of somites from the embryonic mesoderm and their later differentiation.
	71. 1892 Accesses	Research article Environmental stresses can alleviate the average deleterious effect of mutations Roy Kishony, Stanislas Leibler Journal of Biology 2003, 2:14 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology
	72. 1859 Accesses	Minireview Islands in the sky: the impact of Pleistocene climate cycles on biodiversity Allan J Baker Journal of Biology 2008, 7:32 (3 November 2008) Abstract \| Full text \| PDF \| PubMed
	73. 1835 Accesses	Minireview Apical polarity in three-dimensional culture systems: where to now? Jamie L Inman, Mina J Bissell Journal of Biology 2010, 9:2 (21 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	74. 1796 Accesses	Question & Answer Q&A: Cooperativity James E Ferrell Journal of Biology 2009, 8:53 (16 June 2009) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary James Ferrell explains in Q&A format how cooperativity can tune the behaviour of biological macromolecules to their physiological functions, and can be achieved in many different ways.
	75. 1791 Accesses	Minireview RNA interference in nematodes and the chance that favored Sydney Brenner Marie-Anne Félix Journal of Biology 2008, 7:34 (13 November 2008) Abstract \| Full text \| PDF \| PubMed
	76. 1770 Accesses	Minireview Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology Andrew D Peel Journal of Biology 2009, 8:106 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Peel discusses the merits of the flour beetle over the fruit fly as a new arthropod model organism and describes how a new mutagenesis screen published in BMC Biology increases the usefulness of this creature.
	77. 1768 Accesses	Minireview Infectious causes of cancer and their detection Lucy Dalton-Griffin, Paul Kellam Journal of Biology 2009, 8:67 (11 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Lucy Dalton-Griffin and Paul Kellam discuss the role of viruses in cancer following a recent paper in BMC Medical Genomics describing a new method of detecting viral DNA in cancer cells.
	78. 1756 Accesses	Minireview The THO complex as a key mRNP biogenesis factor in development and cell differentiation Sonia Jimeno, Andrés Aguilera Journal of Biology 2010, 9:6 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The THO complex is implicated in RNA export from the nucleus, but exactly how is not clear. Jimeno and Aguilera discuss a new report on the THOC5 subunit in BMC Biology that suggests a role in differentiation.
	79. 1726 Accesses	Minireview The transcriptome of human monocyte subsets begins to emerge Fernando O Martinez Journal of Biology 2009, 8:99 (23 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Monocytes are circulating cells that can differentiate into macrophages with either repair and maintenance or inflammatory properties. Martinez discusses recent papers, including one published in BMC Genomics, that help define these distinct properties and thus identify therapeutic targets.
	80. 1710 Accesses	Minireview Exploiting the promiscuity of imatinib Shun J Lee, Jean YJ Wang Journal of Biology 2009, 8:30 (15 April 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Lee and Wang discuss how the structural flexibility of the cancer drug imatinib (Gleevec) accounts for the drug's off-target promiscuity, illustrated by a structural study published in BMC Structural Biology.
	81. 1708 Accesses	Research article Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm Tadashi Okubo, Brigid LM Hogan Journal of Biology 2004, 3:11 (8 June 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Abnormal activation of the Wnt signaling pathway can alter the fate of progenitor cells that normally generate the lung, causing them to create gut cells instead.
	82. 1700 Accesses	Minireview Cryptic biodiversity in a changing world Luciano B Beheregaray, Adalgisa Caccone Journal of Biology 2007, 6:9 (21 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	83. 1670 Accesses	Minireview Vernalization in cereals Elizabeth S Dennis, W James Peacock Journal of Biology 2009, 8:57 (22 June 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Elizabeth Dennis and James Peacock review recent advances in the molecular basis of the vernalization response that, with the increase in day length at the end of the winter season, triggers flowering.
	84. 1663 Accesses	Research article The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal Jens Böse, Achim D Gruber, Laura Helming, Stefanie Schiebe, Ivonne Wegener, Martin Hafner, Marianne Beales, Frank Köntgen, Andreas Lengeling Journal of Biology 2004, 3:15 (23 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The phosphatidylserine receptor is not needed for the recognition of dying cells as previously thought, and instead plays a role in the differentiation of a wide range of tissues during embryogenesis.
	85. 1623 Accesses	Research article Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function Owain R Millington, Caterina Di Lorenzo, R Phillips, Paul Garside, James M Brewer Journal of Biology 2006, 5:5 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hemozoin pigment, released during malarial infection, is now known to cause dendritic cell failure and subsequent host immunosupression, explaining why people with malaria become prone to infection and respond poorly to vaccines.
	86. 1606 Accesses	Research article Identification of conserved regulatory elements by comparative genome analysis Boris Lenhard, Albin Sandelin, Luis Mendoza, Pär Engström, Niclas Jareborg, Wyeth W Wasserman Journal of Biology 2003, 2:13 (22 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	87. 1595 Accesses	Research article Systematic identification of regulatory proteins critical for T-cell activation Peter Chu, Jorge Pardo, Haoran Zhao, Connie C Li, Erlina Pali, Mary M Shen, Kunbin Qu, Simon X Yu, Betty CB Huang, Peiwen Yu, Esteban S Masuda, Susan M Molineaux, Frank Kolbinger, Gregorio Aversa, Jan de Vries, Donald G Payan, X Charlene Liao Journal of Biology 2003, 2:21 (15 September 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	88. 1587 Accesses	Research article Adaptive evolution of centromere proteins in plants and animals Paul B Talbert, Terri D Bryson, Steven Henikoff Journal of Biology 2004, 3:18 (31 August 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Centromere-binding proteins, like the DNA they bind, are rapidly evolving, a remarkable finding given that they are essential for every cell division and so would be expected to be very highly conserved.
	89. 1570 Accesses	Minireview Adaptation by introgression Michael L Arnold, Noland H Martin Journal of Biology 2009, 8:82 (13 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	90. 1548 Accesses	Minireview Reprogramming of the non-coding transcriptome during brain development Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.
	91. 1544 Accesses	Question & Answer Q&A: What can microfluidics do for stem-cell research? Marie Csete Journal of Biology 2010, 9:1 (11 February 2010) Full text \| PDF \| PubMed
	92. 1536 Accesses	Minireview Dishevelled and Wnt signaling: is the nucleus the final frontier? Raymond Habas, Igor B Dawid Journal of Biology 2005, 4:2 (17 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	93. 1530 Accesses	Minireview Limb regeneration revisited Jessica L Whited, Clifford J Tabin Journal of Biology 2009, 8:5 (13 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	94. 1530 Accesses	Minireview Malaria pigment paralyzes dendritic cells Britta C Urban, Stephen Todryk Journal of Biology 2006, 5:4 (12 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	95. 1518 Accesses	Opinion Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system Brigitta Stockinger Journal of Biology 2009, 8:61 (17 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Brigitta Stockinger argues that the immunosuppressive effects of dioxin and other toxic aryl hydrocarbons may reflect disruption of the regulatory interactions between immune cells, which variably express the specific receptor for these compounds.
	96. 1514 Accesses	Minireview The future of artemisinins: natural, synthetic or recombinant? Marcel Hommel Journal of Biology 2008, 7:38 (15 December 2008) Abstract \| Full text \| PDF \| PubMed
	97. 1509 Accesses	Review The ribosome returned Peter B Moore Journal of Biology 2009, 8:8 (26 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	98. 1505 Accesses	Research article Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling Keiji Itoh, Barbara K Brott, Gyu-Un Bae, Marianne J Ratcliffe, Sergei Y Sokol Journal of Biology 2005, 4:3 (15 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, doesn't only function in the cytoplasm and at the cell membrane, but must be imported into the nucleus to perform at least one key aspect of its function.
	99. 1502 Accesses	Minireview X-chromosome inactivation: the molecular basis of silencing Barbara Panning Journal of Biology 2008, 7:30 (27 October 2008) Abstract \| Full text \| PDF \| PubMed
	100. 1499 Accesses	Research article A quantitative analysis of the mechanism that controls body size in Manduca sexta HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.